Abstract
Prins reaction is a very useful and important reaction in the field of synthetic organic
chemistry. Prins cyclization is one of the greatest significant synthetic approaches in the total synthesis
of various natural compounds especially pyran and furan units. The addition of aldehydes to olefinic
compounds utilizing acid catalyst has become important for the industry.
Aldehydes and alkenes to give different products depending on the reaction conditions, yield an acidcatalyzed
reaction. Formation of Carbon-Carbon bonds is useful to produce 1,3-diol, 1,3-dioxane, β-
halohydrin and allylic alcohols and tetrahydropyrans by using this methodology. Now coming to the
point of tandem Prins cyclization, this method is very useful for the synthesis of fused compounds
and also for the construction of spirocyclic compounds such as tetrahydropyrans or furans. The present
brief review mainly deals with the development of the synthesis of oxygen-containing heterocyclic
compounds by using prins/tandem prins cyclization. This current review is focused mainly on
tandem prins cyclization’s reactions for the particular recent applications and what methods are used
for the construction of the oxygen contained heterocyclic compounds.
Keywords:
Prins cyclization, pyran and furan units, 1, 3-diol, 3-dioxane, β-halohydrin, tetrahydropyrans.
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