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Letters in Organic Chemistry

Author(s): Kooi-Mow Sim*, Pei-Theng Leong, Wai-Sum Wong and Kah-Cheng Teo

DOI: 10.2174/1570178619666220520142238

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Synthesis and Characterization of Some New Spirothiadiazole Oxindoles and their Mannich Bases

Page: [1136 - 1140] Pages: 5

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Abstract

A series of new spirothiadiazole oxindoles were synthesized by the reaction of 4-amino-5- mercapto-3-[(1H-indol-3-yl)methyl]-1,2,4-triazole and isatin derivatives. The reaction of spiro [indole] thiadiazoles with formaldehyde and piperidine afforded the corresponding Mannich bases. The structures of newly synthesized compounds were characterized by IR, 1D-NMR, 2D-NMR, and LC/MS spectral data.

Keywords: 1, 2, 4-triazole, isatin, spirothiadiazole oxindole, condensation, mannich base, heterocyclic compound.

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