Molecular Iodine-Catalyzed N-Benzylic Sulfonamides C-N Bond Cleavage
for the Decarboxylative Substitution of β-Keto Acids

Lina      Jia; Jinyu      Zhao; Xiangping      Hu
Abstract

A molecular iodine-catalyzed system for the decarboxylative substitution reactions of β-keto acids with N-benzylic sulfonamides via sp³ C-N bond cleavage has been disclosed. This procedure provides a series of α-functionalized ketones in good to excellent yields. Furthermore, the practicability of this method could be manifested efficiently in a gram-scale synthesis.
Keywords: Decarboxylative Substitution, iodine, N-benzylic sulfonamide, C-N bond cleavage, β-keto acids, sp³.
Graphical Abstract

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Cite As
Letters in Organic Chemistry

Molecular Iodine-Catalyzed N-Benzylic Sulfonamides C-N Bond Cleavage for the Decarboxylative Substitution of β-Keto Acids

Abstract

Graphical Abstract
