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Letters in Organic Chemistry

Author(s): Zohreh Hashemi Beni, Jalal Albadi*, Hamzeh Kiyani and Heshmat Allah Samimi Shalamzari

DOI: 10.2174/1570178619666220516123639

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Efficient One-pot Synthesis of Pyrano[2,3-d]pyrimidinone Derivatives Catalyzed by a Novel and Recyclable CuO/NiO Nanocatalyst

Page: [1101 - 1109] Pages: 9

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Abstract

Background: In this study, the synthesis and characterization of a novel kind of NiO-supported CuO nanoparticles (CuO/NiO nanocatalyst), as an efficient and recyclable catalyst, were carried out.

Methods: Nanocatalyst was characterized by XRD, BET, FESEM, EDS, HRTEM, TGA and DSC analysis. It was used in the three-component synthesis reaction between barbituric acid, malononitrile and various aromatic aldehydes for the synthesis of pyrano[2,3-d]pyrimidinone derivatives.

Results: The advantages of using CuO/NiO nanocatalyst in this reaction are high yields of products, a decrease in the reaction times and easy separation of catalyst from the reaction mixture, and the reaction being performed in one-pot.

Conclusion: The CuO/NiO nanocatalyst can be recycled for five consecutive cycles without significant degradation in its catalytic activity.

Keywords: CuO-NiO nanocatalyst, pyrano[2, 3-d]pyrimidinone, three-component reactions, aldehyde, malononitrile, one-pot synthesis.

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