Generic placeholder image

Cardiovascular & Hematological Agents in Medicinal Chemistry

Author(s): Ismail Bouadid, Ayoub Amssayef and Mohamed Eddouks*

DOI: 10.2174/1871525720666220512154041

DownloadDownload PDF Flyer Cite As
Study of the Antihypertensive Effect of Laurus nobilis in Rats

Page: [42 - 54] Pages: 13

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Aims: The study aimed to study the antihypertensive activity of Laurus nobilis.

Background: Laurus nobilis L. is used to treat hypertension in Morocco.

Objective: The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.

Materials and Methods: The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.

Results: A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.

Conclusion: The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.

Keywords: Laurus nobilis, medicinal plant, hypertension, blood pressure, vasorelaxant activity, ACE-2.

[1]
WHO Global Atlas on Cardiovascular Disease Prevention and Control World Health Organization in Collaboration with the World Heart Federation and the World Stroke Organization; WHO press: Geneva, CH, Switzerland, 2013, p. 1211.
[2]
Chow, C-K.; Teo, K-K.; Rangarajan, S.; Islam, S.; Gupta, R.; Avezum, A.; Bahonar, A.; Chifamba, J.; Dagenais, G.; Diaz, R.; Kazmi, K.; Lanas, F.; Wei, L.; Lopez-Jaramillo, P.; Fanghong, L.; Ismail, N.H.; Puoane, T.; Rosengren, A.; Szuba, A.; Temizhan, A.; Wielgosz, A.; Yusuf, R.; Yusufali, A.; McKee, M.; Liu, L.; Mony, P.; Yusuf, S. PURE (Prospective Urban Rural Epidemiology) Study investigators. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA, 2013, 310(9), 959-968.
[http://dx.doi.org/10.1001/jama.2013.184182] [PMID: 24002282]
[3]
Kiriyama, A.; Honbo, A.; Nishimura, A.; Shibata, N.; Iga, K. Pharmacokinetic-pharmacodynamic analyses of antihypertensive drugs, nifedipine and propranolol, in spontaneously hypertensive rats to investigate characteristics of effect and side effects. Regul. Toxicol. Pharmacol., 2016, 76, 21-29.
[http://dx.doi.org/10.1016/j.yrtph.2016.01.003] [PMID: 26773344]
[4]
Singh, P.; Mishra, A.; Singh, P. Hypertension and herbal plant for its treatment. Review Ind. J. Res. Pharm. Biotech., 2015, 3(5), 358-366.
[5]
Eddouks, M.; Maghrani, M.; Lemhadri, A.; Ouahidi, M-L.; Jouad, H. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J. Ethnopharmacol., 2002, 82(2-3), 97-103.
[http://dx.doi.org/10.1016/S0378-8741(02)00164-2] [PMID: 12241983]
[6]
Eddouks, M.; Ajebli, M.; Hebi, M. Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco. J. Ethnopharmacol., 2017, 198, 516-530.
[http://dx.doi.org/10.1016/j.jep.2016.12.017] [PMID: 28003130]
[7]
Nafis, A.; Kasrati, A. AlaouiJamali, C.; Custódio, L.; Vitalini, S.; Iriti, M.; Hassani, L. A comparative study of the in vitro antimicrobial and synergistic effect of essential oils from Laurus nobilis L. and Prunus armeniaca L. from morocco with antimicrobial drugs: New approach for health promoting products. J. Antibiot. (Tokyo), 2020, 9, 140.
[http://dx.doi.org/10.3390/antibiotics9040140]
[8]
Caputo, L.; Nazzaro, F.; Souza, L-F.; Aliberti, L.; De Martino, L.; Fratianni, F.; Coppola, R.; De Feo, V. Laurus nobilis: Composition of essential oil and its biological activities. Molecules, 2017, 22(6), 930.
[http://dx.doi.org/10.3390/molecules22060930] [PMID: 28587201]
[9]
Lee, E-H.; Shin, J-H.; Kim, S-S. Laurus nobilis leaf extract controls inflammation by suppressing NLRP3 inflammasome activation. J. Cell. Physiol., 2019, 234(5), 6854-6864.
[10]
Merghni, A.; Marzouki, H.; Hentati, H.; Aouni, M.; Mastouri, M. Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections. Pathol. Biol. 2015. S0369-8114(15)00101-7
[11]
Belasli, A.; Ben Miri, Y.; Aboudaou, M. AïtOuahioune, L.; Montañes, L.; Ariño, A.; Djenane, D. Antifungal, antitoxigenic, and antioxidant activities of the essential oil from laurel (Laurus nobilis L.): Potential use as wheat preservative. J. Food Sci. Nutr., 2020, 8(9), 4717-4729.
[12]
Fidan, H.; Stefanova, G.; Kostova, I.; Stankov, S.; Damyanova, S.; Stoyanova, A.; Zheljazkov, V-D. Chemical composition and antimicrobial activity of Laurus nobilis L. essential oils from Bulgaria. Molecules, 2019, 24(4), 804.
[http://dx.doi.org/10.3390/molecules24040804] [PMID: 30813368]
[13]
Stefanova, G.; Girova, T.; Gochev, V.; Stoyanova, M.; Petkova, Z.; Stoyanova, A.; Zheljazkov, A.-D. Comparative study on the chemical composition of laurel (Laurus nobilis L.) leaves from Greece and Georgia and the antibacterial activity of their essential oil. J. heliyon, 2020. e05491
[14]
Qnais, E-Y.; Abdulla, F-A.; Kaddumi, E-G.; Abdalla, S-S. Antidiarrheal activity of Laurus nobilis L. leaf extract in rats. J. Med. Food, 2012, 15(1), 51-57.
[http://dx.doi.org/10.1089/jmf.2011.1707] [PMID: 22082096]
[15]
Ziyyat, A.; Legssyer, A.; Mekhfi, H.; Dassouli, A.; Serhrouchni, M.; Benjelloun, W. Phytotherapy of hypertension and diabetes in oriental Morocco. J. Ethnopharmacol., 1997, 58(1), 45-54.
[http://dx.doi.org/10.1016/S0378-8741(97)00077-9] [PMID: 9324004]
[16]
Farid, O.; Hebi, M.; Ajebli, M.; Hidani, A.E.; Eddouks, M. Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats. J. Basic Clin. Physiol. Pharmacol., 2017, 28(3), 275-282.
[http://dx.doi.org/10.1515/jbcpp-2016-0030] [PMID: 28121617]
[17]
Ajebli, M.; Eddouks, M. Buxus sempervirens L. improves streptozotocin-induced diabetes mellitus in rats. Cardiovasc. Hematol. Disord. Drug Targets, 2017, 17(2), 142-152.
[http://dx.doi.org/10.2174/1871529X17666170918140817] [PMID: 28925906]
[18]
Amssayef, A.; Eddouks, M. Aqueous extract of Matricaria pubescens exhibits antihypertensive activity in l-name-induced hypertensive rats through its vasorelaxant effect. J. Cardiovasc. Hematol. Agents Med. Chem., 2019, 17(2), 135-143.
[http://dx.doi.org/10.2174/1871525717666191007151413] [PMID: 31589128]
[19]
Ajebli, M.; Eddouks, M. Eucalyptus globulus possesses antihypertensive activity in L-NAME-induced hypertensive rats and relaxes isolated rat thoracic aorta through nitric oxide pathway. J. Nat. Prod. Res, 2019, 10, 1-3.
[PMID: 30966776]
[20]
Amssayef, A.; Ajebli, M.; Eddouks, M. Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway. J. Clin. Exp. Hypertens, 2021, 43(1), 49-55.
[http://dx.doi.org/10.1080/10641963.2020.1797087] [PMID: 32706597]
[21]
Kim, B.; Kwon, Y.; Lee, S.; Lee, K.; Ham, I.; Choi, H.Y. Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings. BMC Complement. Altern. Med., 2017, 17(1), 474.
[http://dx.doi.org/10.1186/s12906-017-1965-z] [PMID: 28969672]
[22]
Ajebli, M.; Eddouks, M. Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats. J. Ethnopharmacol., 2019, 242, 112039.
[http://dx.doi.org/10.1016/j.jep.2019.112039] [PMID: 31252093]
[23]
Hoe, S-Z.; Lee, C-N.; Mok, S-L.; Kamaruddin, M.Y.; Lam, S.K. Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels. Clinics (São Paulo), 2011, 66(1), 143-150.
[http://dx.doi.org/10.1590/S1807-59322011000100025] [PMID: 21437451]
[24]
Karaki, H.; Ozaki, H.; Hori, M.; Mitsui-Saito, M.; Amano, K.; Harada, K.; Miyamoto, S.; Nakazawa, H.; Won, K.J.; Sato, K. Calcium movements, distribution, and functions in smooth muscle. Pharmacol. Rev., 1997, 49(2), 157-230.
[PMID: 9228665]
[25]
He, J.Y.; Zhang, W.; He, L.C.; Cao, Y.X. Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release. Eur. J. Pharmacol., 2007, 573(1-3), 170-175.
[http://dx.doi.org/10.1016/j.ejphar.2007.06.043] [PMID: 17662269]
[26]
Ajebli, M.; Eddouks, M. Vasorelaxant and antihypertensive effects of mentha pulegium l. in rats: An in vitro and in vivo approach. Endocr. Metab. Immune Disord. Drug Targets, 2021, 21(7), 1289-1299.
[http://dx.doi.org/10.2174/1871530320666200909093908]
[27]
Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S. A novel Angiotensin-Converting Enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res., 2000, 87(5), E1-E9.
[http://dx.doi.org/10.1161/01.RES.87.5.e1] [PMID: 10969042]
[28]
Gheblawi, M.; Wang, K.; Viveiros, A.; Nguyen, Q.; Zhong, J-C.; Turner, A-J.; Raizada, M-K.; Grant, M-B.; Oudit, G-Y. Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: Celebrating the 20th anniversary of the discovery of ACE2. Circ. Res., 2020, 126(10), 1456-1474.
[http://dx.doi.org/10.1161/CIRCRESAHA.120.317015] [PMID: 32264791]
[29]
Rice, G-I.; Thomas, D-A.; Grant, P-J.; Turner, A-J.; Hooper, N-M. Evaluation of Angiotensin-Converting Enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem. J., 2004, 383(Pt 1), 45-51.
[http://dx.doi.org/10.1042/BJ20040634] [PMID: 15283675]