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Current Enzyme Inhibition

Author(s): Victor Markus, Özlem Dalmızrak, Kerem Teralı and Nazmi Özer*

DOI: 10.2174/1573408018666220428100417

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The Inhibition of Glutathione S-Transferases and Butyrylcholinesterase by Antidepressants: A Mini-Review on Enzyme-Drug Interactions

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Abstract

Background: Compromises in the cellular enzymatic defense barrier can increase the duration of exposure to electrophiles and the severity of toxicity they may incur.

Objective: In this mini-review, we discuss the inhibition of the enzymatic defense systems by different antidepressants commonly prescribed worldwide as well as herbal products used for various forms of depression.

Methods: Our work primarily focused on the interactions of two prominent biotransformation enzyme systems, namely glutathione S-transferases and cholinesterases, with tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and hypericin.

Results: The antidepressants exert considerable inhibitory effects against glutathione -transferases and butyrylcholinesterase.

Conclusion: The outcomes of available published studies and their implications for health and disease are discussed here in detail.

Keywords: Major depression, tricyclic antidepressants, selective serotonin reuptake inhibitors, hypericin, glutathione S-transferases, cholinesterases.

Graphical Abstract

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