Generic placeholder image

Cardiovascular & Hematological Agents in Medicinal Chemistry

Author(s): Maryam Rezaei, Reza Khazaei, Zabihullah Mohaqiq, Vajehallah Raeesi*, Tahereh Farkhondeh and Saeed Samarghandian*

DOI: 10.2174/1871525720666220425120457

DownloadDownload PDF Flyer Cite As
Effect of Magnesium Status on Microalbuminuria in Type 2 Diabetic Patients

Page: [55 - 59] Pages: 5

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Background: There are several controversies regarding the association between serum magnesium depletion and microalbuminuria in type 2 diabetic patients.

Objective: Therefore, this study aimed to assess serum magnesium concentrations in Type 2 diabetic patients with microalbuminuria and normoalbuminuria in Birjand, Iran, in 2019.

Methods: In this cross-sectional study, 25 type 2 diabetes patients with microalbuminuria were enrolled as the case group and 25 type 2 diabetes patients with normoalbuminuria as the control group. Both groups were matched for age, sex, hypertension, and dyslipidemia. Blood samples were obtained for serum magnesium measurement.

Results: Our findings showed no significant difference between serum magnesium concentration in the case and control groups (mean serum magnesium concentration for case group: 2.34 ± 0.35 mg/dl and control group: 2.27 ± 0.33 mg/dl). Pearson correlation coefficient analysis did not show any correlation between serum magnesium levels and urine albumin levels in patients with microalbuminuria versus patients with normoalbuminuria (r = 0.06, p = 0.67).

Conclusion: This study did not indicate a correlation between serum magnesium concentrations and microalbuminuria in Type 2 diabetic patients.

Keywords: Serum magnesium concentration, microalbuminuria, Type 2 diabetes, hypertension and dyslipidemia, blood samples, Pearson correlation coefficient analysis.

[1]
Sadeghian, M.; Azadbakht, L.; Khalili, N.; Mortazavi, M.; Esmaillzadeh, A. Oral magnesium supplementation improved lipid profile but increased insulin resistance in patients with diabetic nephropathy: A double-blind randomized controlled clinical trial. Biol. Trace Elem. Res., 2020, 193(1), 23-35.
[http://dx.doi.org/10.1007/s12011-019-01687-6] [PMID: 30835085]
[2]
Khadka, B.; Tiwari, M.L.; Timalsina, B.; Risal, P.; Gupta, S.; Acharya, D. Prevalence and factors associated with microalbuminuria among type 2 diabetic patients: A hospital based study. JNMA J. Nepal Med. Assoc., 2018, 56(209), 516-521.
[http://dx.doi.org/10.31729/jnma.3469] [PMID: 30058635]
[3]
Ebrahimi, Z.S.; Nasli-Esfahani, E.; Nadjarzade, A.; Mozaffari-Khosravi, H. Effect of symbiotic supplementation on glycemic control, lipid profiles and microalbuminuria in patients with non-obese type 2 diabetes: A randomized, double-blind, clinical trial. J. Diabetes Metab. Disord., 2017, 16(1), 23.
[http://dx.doi.org/10.1186/s40200-017-0304-8] [PMID: 28589103]
[4]
Xu, B.; Sun, J.; Deng, X.; Huang, X.; Sun, W.; Xu, Y.; Xu, M.; Lu, J.; Bi, Y. Low serum magnesium level is associated with microalbumi-nuria in Chinese diabetic patients. Int. J. Endocrinol., 2013, 2013, 580685.
[http://dx.doi.org/10.1155/2013/580685] [PMID: 24065990]
[5]
Futrakul, N.; Futrakul, P. Biomarker for early renal microvascular and diabetic kidney diseases. Ren. Fail., 2017, 39(1), 505-511.
[http://dx.doi.org/10.1080/0886022X.2017.1323647] [PMID: 28494191]
[6]
Arpaci, D.; Tocoglu, A.G.; Ergenc, H.; Korkmaz, S.; Ucar, A.; Tamer, A. Associations of serum magnesium levels with diabetes mellitus and diabetic complications. Hippokratia, 2015, 19(2), 153-157.
[PMID: 27418765]
[7]
Pickup, J.C.; Chusney, G.D.; Crook, M.A.; Viberti, G.C. Hypomagnesaemia in IDDM patients with microalbuminuria and clinical pro-teinuria. Diabetologia, 1994, 37(6), 639-640.
[http://dx.doi.org/10.1007/BF00403385] [PMID: 7926351]
[8]
Allegra, A.; Corsonello, A.; Buemi, M.; D’Angelo, R.; di Benedetto, A.; Bonanzinga, S.; Cucinotta, D.; Ientile, R.; Corica, F. Plasma, eryth-rocyte and platelet magnesium levels in type 1 diabetic patients with microalbuminuria and clinical proteinuria. J. Trace Elem. Med. Biol., 1997, 11(3), 154-157.
[http://dx.doi.org/10.1016/S0946-672X(97)80044-2] [PMID: 9442461]
[9]
Mirrahimi, B.; Hamishehkar, H.; Ahmadi, A.; Mirjalili, M.R.; Aghamohamadi, M.; Najafi, A.; Abdollahi, M.; Mojtahedzahed, M. The effi-cacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing. Daru, 2012, 20(1), 74.
[http://dx.doi.org/10.1186/2008-2231-20-74] [PMID: 23351890]
[10]
Al-Fartosy, A.J.M.; Awad, N.A.; Alsalimi, S.A. Clinical markers and some trace elements in patients with type-2 diabetic nephropathy: Impact of insulin resistance. J. Med. Invest., 2021, 68, 76-84.
[11]
Resnick, J.M.; Altura, B.T.; Gupta, R.K.; Laragh, J.H.; Alderman, M.H.; Altura, B.M. Intracellular and extracellular magnesium depletion in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 1993, 36(8), 767-770.
[12]
Buragohain, R.; Sood, A.; Pandey, S.K.; Kanta Goswami, R. Correlation of serum magnesium level with microalbuminuria in type 2 diabetes mellitus. J. Evid. Based Med. Heal., 7(32), 1617-1622.
[13]
Zargar, A.H.; Bashir, M.I.; Masoodi, S.R.; Laway, B.A.; Wani, A.I.; Khan, A.R.; Dar, F.A. Copper, zinc and magnesium levels in type-1 diabetes mellitus. Saudi Med. J., 2002, 23(5), 539-542.
[PMID: 12070576]
[14]
Sales, C.H.; Pedrosa, L.F.C.; Lima, J.G.; Lemos, T.M.; Colli, C. Influence of magnesium status and magnesium intake on the blood glu-cose control in patients with type 2 diabetes. Clin. Nutr., 2011, 30(3), 359-364.
[http://dx.doi.org/10.1016/j.clnu.2010.12.011] [PMID: 21288611]
[15]
Corsonello, A.; Ientile, R.; Buemi, M.; Cucinotta, D.; Mauro, V.N.; Macaione, S.; Corica, F. Serum ionized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical proteinuria. Am. J. Nephrol., 2000, 20(3), 187-192.
[http://dx.doi.org/10.1159/000013582] [PMID: 10878399]
[16]
Aneesh, T.; Rao, M.Y. Serum magnesium in type 2 diabetic patients with microalbuminuria and overt proteinuria. IOSR J. Dent. Med. Sci., 2016, 15, 30-35.
[17]
Azad, K.M.; Sutradhar, S.R.; Khan, N.A.; Haque, M.F.; Sumon, S.M.; Barman, T.K.; Islam, M.Z.; Haque, M.R.; Pandit, H.; Ahmed, S. Serum magnesium in hospital admitted diabetic patients. Mymensingh Med. J., 2014, 23(1), 28-34.
[PMID: 24584369]
[18]
Arslanoğlu, I.; Günöz, H.; Bundak, R.; Saka, N. Hypomagnesaemia in childhood IDDM and risk of nephropathy. Diabetologia, 1995, 38(5), 629.
[http://dx.doi.org/10.1007/BF00400735] [PMID: 7489849]
[19]
Ma, J.; Folsom, A.R.; Melnick, S.L.; Eckfeldt, J.H.; Sharrett, A.R.; Nabulsi, A.A.; Hutchinson, R.G.; Metcalf, P.A. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: The ARIC study. Atherosclerosis risk in communities study. J. Clin. Epidemiol., 1995, 48(7), 927-940.
[http://dx.doi.org/10.1016/0895-4356(94)00200-A] [PMID: 7782801]
[20]
Ascherio, A.; Rimm, E.B.; Hernán, M.A.; Giovannucci, E.L.; Kawachi, I.; Stampfer, M.J.; Willett, W.C. Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men. Circulation, 1998, 98(12), 1198-1204.
[http://dx.doi.org/10.1161/01.CIR.98.12.1198] [PMID: 9743511]
[21]
Corica, F.; Allegra, A.; Di Benedetto, A.; Giacobbe, M.S.; Romano, G.; Cucinotta, D.; Buemi, M.; Ceruso, D. Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Magnes. Res., 1994, 7(1), 43-47.
[PMID: 8054260]
[22]
Vatsalya, V.; Gala, K.S.; Mishra, M.; Schwandt, M.L.; Umhau, J.; Cave, M.C.; Parajuli, D.; Ramchandani, V.A.; McClain, C.J. Lower se-rum magnesium concentrations are associated with specific heavy drinking markers, pro-inflammatory response and early-stage alcohol-associated liver injury§. Alcohol Alcohol., 2020, 55(2), 164-170.
[http://dx.doi.org/10.1093/alcalc/agaa001] [PMID: 32047901]
[23]
Wang, C.H.; Wei, Y.H. Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin re-sistance and type 2 diabetes. J. Biomed. Sci., 2017, 24(1), 70.
[http://dx.doi.org/10.1186/s12929-017-0375-3] [PMID: 28882140]
[24]
Zitouni, K.; Steyn, M.R.C.P.; Lyka, E.; Kelly, F.J.; Cook, P.; Ster, I.C.; Earle, K.A. Derepression of glomerular filtration, renal blood flow and antioxidant defence in patients with type 2 diabetes at high-risk of cardiorenal disease. Free Radic. Biol. Med., 2020, 161, 283-289.
[http://dx.doi.org/10.1016/j.freeradbiomed.2020.10.005] [PMID: 33039650]
[25]
Rao, P.P.; Shariff, M.G. Serum magnesium levels in type 2 diabetic patients with microalbuminuria and normoalbuminuria. Int. J. Sci. Stud., 2015, 3(4), 11-15.