Generic placeholder image

Venoms and Toxins

Author(s): Maria Elena de Lima* and Kênia Pedrosa Nunes

DOI: 10.2174/2666121702666220425111433

Cite As
Drugs from Animal Venoms: Overcoming the Challenges to Treat Erectile Dysfunction

Article ID: e250422204001 Pages: 2

  • * (Excluding Mailing and Handling)

[1]
Ferreira SH. Bradykinin-Potentiating Factor. Hypotensive Peptides, Springer Berlin Heidelberg, Berlin. Heidelberg 1966; pp. 356-67.
[http://dx.doi.org/10.1007/978-3-642-94965-4_35]
[2]
Miljanich GP. Ziconotide: Neuronal calcium channel blocker for treating severe chronic pain. Curr Med Chem 2004; 11(23): 3029-40.
[http://dx.doi.org/10.2174/0929867043363884] [PMID: 15578997]
[3]
Malone J, Trautmann M, Wilhelm K, Taylor K, Kendall DM. Exenatide once weekly for the treatment of type 2 diabetes. Null 2009; 18(3): 359-67.
[http://dx.doi.org/10.1517/13543780902766802] [PMID: 19243286]
[4]
Herzig V, Cristofori-Armstrong B, Israel MR, Nixon SA, Vetter I, King GF. Animal toxins - Nature’s evolutionary-refined toolkit for basic research and drug discovery. Biochem Pharmacol 2020; 181: 114096.
[http://dx.doi.org/10.1016/j.bcp.2020.114096] [PMID: 32535105]
[5]
Lima M, Figueiredo S, Matavel A, et al. Phoneutria nigriventer venom and toxins: A review. In: Gopalakrishnakone P, Corzo G, de Lima M, Diego-García E, Eds. Spider Venoms Toxinology. Springer, Dordrecht.
[http://dx.doi.org/10.1007/978-94-007-6389-0_6]
[6]
Peigneur S, de Lima ME, Tytgat J. Phoneutria nigriventer venom: A pharmacological treasure. Toxicon 2018; 151: 96-110.
[http://dx.doi.org/10.1016/j.toxicon.2018.07.008] [PMID: 30003916]
[7]
Nunes KP, Costa-Gonçalves A, Lanza LF, et al. Tx2-6 toxin of the Phoneutria nigriventer spider potentiates rat erectile function. Toxicon 2008; 51(7): 1197-206.
[http://dx.doi.org/10.1016/j.toxicon.2008.02.010] [PMID: 18397797]
[8]
Nunes KP, Wynne BM, Cordeiro MN, et al. Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO/cGMP signaling. Int J Impot Res 2012; 24(2): 69-76.
[http://dx.doi.org/10.1038/ijir.2011.47] [PMID: 21975567]
[9]
Dean RC, Lue TF. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am 2005; 32(4): 379-95.
[http://dx.doi.org/10.1016/j.ucl.2005.08.007] [PMID: 16291031]
[10]
Najari BB, Kashanian JA. Erectile dysfunction. JAMA 2016; 316(17): 1838-8.
[http://dx.doi.org/10.1001/jama.2016.12284] [PMID: 27802547]
[11]
da Silva CN, Pedrosa KN, da Silva GC. The synthetic peptide PnPP-19 potentiates erectile function via nNOS and iNOS. Nitric Oxide 2021; 113–114: 23-30.
[http://dx.doi.org/10.1016/j.niox.2021.04.007]
[12]
Torres FS, Silva CN, Lanza LF, et al. Functional expression of a recombinant toxin - rPnTx2-6 - active in erectile function in rat. Toxicon 2010; 56(7): 1172-80.
[http://dx.doi.org/10.1016/j.toxicon.2010.04.010] [PMID: 20417652]
[13]
Silva CN, Nunes KP, Torres FS, et al. PnPP-19, a synthetic and non toxic peptide designed from a P. nigriventer toxin, potentiates erectile function via NO/cGMP. J Urol 2015; 194(5): 1481-90.
[http://dx.doi.org/10.1016/j.juro.2015.06.081] [PMID: 26119670]
[14]
Nunes da Silva C, Nunes KP, De Marco Almeida F, et al. PnPP-19 Peptide restores erectile function in hypertensive and diabetic animals through intravenous and topical administration. J Sex Med 2019; 16(3): 365-74.
[http://dx.doi.org/10.1016/j.jsxm.2019.01.004] [PMID: 30773502]