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Current Medicinal Chemistry

Author(s): Fabiola De Luca, Carla Di Chio, Maria Zappalà and Roberta Ettari*

DOI: 10.2174/0929867329666220415113219

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Dihydrochalcones as Antitumor Agents

Page: [5042 - 5061] Pages: 20

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Abstract

Dihydrochalcones are a class of secondary metabolites, possessing several biological properties such as antitumor, antioxidant, antibacterial, antidiabetic, estrogenic, anti-inflammatory, antithrombotic, antiviral, neuroprotective, and immunomodulatory properties; therefore, they are currently considered promising candidates in the drug discovery process. This review intends to debate their pharmacological actions with particular attention to their antitumor activity against a panel of cancer cell lines and to the description of the inhibition mechanisms of cell proliferation such as the regulation of angiogenesis, apoptosis, etc.

Keywords: Chalcones, dihydrochalcones, antitumor agents, cell lines, antioxidant, antibacterial.

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