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Letters in Organic Chemistry

Author(s): Ping Li Zeng, Junhui Zhou, Xuechao Yang, Dong Wang* and Zhibing Dong

DOI: 10.2174/1570178619666220408121439

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Concise Synthesis of Goniothalesdiol A

Page: [1145 - 1148] Pages: 4

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Abstract

A concise and efficient synthesis of styryllactone derivative, goniothalesdiol A, has been achieved in the six longest linear steps with 17.7% overall yield. The key steps of our synthesis involved PdCl2-mediated Wacker-type oxidative cyclisation and one-pot tandem Wittig olefination- Michael addition.

Keywords: Total synthesis, goniothalesdiol A, styryllactone, L-erythrose, Wacker oxidation, Wittig olefination-Michael addition.

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