Abstract
Background: Salvia chloroleuca Rech. f. & Allen is an endemic or native perennial medicinal
plant growing wildly in central, north, and northeast Iran.
Objective: The aim of this research was to provide an overview of the chemical profile of Salvia
chloroleuca, the principal chemical compounds, and their various biological activities and uses in
traditional pharmacopoeia.
Methods: The literature search was done via specialized search databases (SciFinder, Scopus, Pub-
Med, Web of Science, and Google Scholar).
Results: From the past to the present, people have consumed Salvia chloroleuca for carminative, antibacterial,
antitumoral, antiviral, antifungal, antiparasitic, antirheumatic, tonic, hepatoprotective,
nephroprotective, immunoprotective, anticancer and neuroprotective properties. The principal ingredients
of Salvia chloroleuca are salvigenin, luteolin, cirsiliol, daucosterol, and β-sitosterol, and
these substances may be responsible for the herb's remedial properties. The bioactive components
extracted from Salvia chloroleuca have promising prospects and make it possible to propose diverse
solutions due to their excellent dissimilarity and bioactivity for such various usages.
Conclusion: This study is a valuable resource for further research and improvement of the varied
features of Salvia chloroleuca secondary metabolites. This study is a valuable source of information
regarding an important native medicinal plant. It can be extended for new investigations in the fields
of phytochemistry and pharmacology, with the purpose of searching for novel natural bioactive
structures with therapeutic properties.
Keywords:
Salvia chloroleuca, essential oil, extracts, pharmacological properties, medicinal plants, bioactive structure.
Graphical Abstract
[7]
Pan SY, Litscher G, Gao SH, et al. Historical perspective of traditional indigenous medical practices: The current renaissance and conservation of herbal resources. eCAM 2014; 1-20.2014.
[10]
Moridi Farimani M, Mirzania F, Sonboli A, Moghaddam FM. Chemical composition and antibacterial activity of dracocephalum kotschyi essential oil obtained by microwave extraction and hydrodistillation Int J Food Prop 2017; 20(sup1): 306-15.
[14]
Hachem K, Benabdesslem Y, Adli DE, Chikhi A, Kahloula K. A review on the phytochemical composition and the traditional medicinal uses of Salvia argentea (Lamiaceae). Sys Rev Pharm 2020; 11(7): 113-8.
[17]
Jamzad Z. A survey of lamiaceae in the flora of Iran. Rostaniha 2013; 14(1): 59-67.
[20]
Sharma Y, Fagan J, Schaefer J. Ethnobotany, phytochemistry, cultivation and medicinal properties of Garden sage (Salvia officinalis L.). J Pharmacogn Phytochem 2019; 8: 3139-48.
[30]
Miraj S, Kiani S. A review study of therapeutic effects of Salvia officinalis L‏. Pharm Lett 2016; 8(6): 19-23.
[36]
Ghahreman A. Index to the scientific names of the 2000 plants presented flora of Iran in natural colors Tehran: Research Institute of Forestes and Rangelands 1996; p 1598.
[38]
Doda Q, Bardhi N, Teqja Z, Mero G, Kallço I, Zeka B. Effects of different limestone rates on yield and yield indicators of a sage (Salvia officinalis L.) Ecotype. Int Multidiscip Res J 2014; 4: 7-16.
[42]
Ali SNF, Sefidkon F, Yousefzadi M, Nemati S, Khajeh PM. Investigation of chemical compositions and antimicrobial effects of essential oils of Salvia chloroleuca Rech. F. Aell. and Nepeta fissa Ca Mey. Iran J Med Aroma Plant 2006; 21: 453-64.
[46]
Hashempour H, Mehmannavaz M, Ebadi M, Abri A, Matin AA, Amani-Ghadim AR. Fatty acid composition analysis of aerial parts of selected Salvia species growing in Iran and chemotaxonomic approach by shoot fatty acid composition. Anal Bioanal Chem Res 2018; 5(2): 297-306.
[59]
Đorđević S, Cakić M, Amr S. The extraction of apigenin and luteolin from the sage Salvia officinalis L. from Jordan. Facta universitatis- series. Work Living Environ Prot 2000; 1(5): 87-93.
[61]
Kang WJ. Chemical constituents of Salvia plebeia. Chin Tradit Herbal Drugs 2015; 24: 1589-92.
[66]
He-Ying WA, De-Yu HU, Wei XU, Song YA, Bao-An SO. Chemical constituents in herb of Salvia cavaleriei lévl. NPRD 2011; 23(1): 63.
[71]
Razavi M, Tehranipour M, Khayatzadeh J. Effects of aqueous extract of Salvia chloroleuca leaves on degeneration of alpha motoneurons in spinal cord after sciatic nerve compression in rat. Shahrekord Univ Med Sci J 2014; 16(2): 22-30.
[72]
Razavi M, Tehranipour M, Khyatzadeh J. Neuroprotective effect of alcoholic extract of Salvia chloroleuca against neuronal degeneration of alpha motoneurons of anterior horn spinal cord after sciatic nerve injury in rats. HMS 2014; 20(3): 151-6.
[74]
Najafi S, Mir N, Shafeghat M. Antioxidant and antibacterial activities of six medicinally important species of the genus Salvia from north east of Iran. J Genet Resour 2016; 2(1): 41-7.
[76]
Salimikia I. HR ME, Sharifzadeh M, Gohari AR, Salek M. α-Amylase inhibitory property, antioxidant activity and toxicological study of Salvia chloroleuca. RJP 2015; 2(1): 7-15.
[78]
Afshari H, Eftekhari M, Faraji M, Ebadi AG, Abbaspour H. Effect of different levels of gibberellic acid on seed sprouting of some species of Salvia genus grown in Iran. J Med Plants Res 2011; 5(18): 4688-90.