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Current Organic Synthesis

Author(s): Komal Chandrakar, Jeevan Lal Patel, Rajeswar Rao Vedula*, R. K. Virendra, Shayama Prasad Mahapatra, Santhosh Penta* and Rajender S. Varma*

DOI: 10.2174/1570179419666220401121714

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Recent Developments in Multi-component Synthesis of Lawsone Derivatives

Page: [278 - 307] Pages: 30

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Abstract

Background: 2-Hydroxy-1,4-Naphthoquinone (HNQ; Lawsone) is one of the most useful and the simplest naturally occurring naphthoquinones and has stimulated a resurgence of interest in the past decades due to a wide range of pharmacological activities.

Introduction and Methods: This activity has led to the unusually large emphasis being placed on the design of more efficient multi-component reactions (MCRs) in the synthesis of bioactive lawsone derivatives.

Results and Conclusion: This review highlights the recent developments in multi-component synthesis of biologically relevant naphthoquinone linked and fused heterocyclic derivatives carried out from 2015 till now.

Keywords: Lawsone derived heterocycles, multi-component reactions, one-pot synthesis, nanocatalysis, ultrasound irradiation, microwave irradiation.

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