Biological Activities and Therapeutic Potential of Irigenin on Gastric,
Lung, Prostate, Breast, and Endometrial Cancer: Pharmacological and
Analytical Aspects

Dinesh   Kumar   Patel

Abstract

Background: Herbal medicines have been used for thousands of years due to their pharmacological activities against different types of human disorders. The biological effectiveness and pharmacological activities of herbal medicines are mainly due to the presence of different kinds of phytoconstituents, commonly called secondary metabolites. Isoflavones are naturally present in different types of plants and food materials, and most of these phytocompounds have a wide range of biological activities, including anti-tumor, anti-proliferative, anti-inflammatory, anti-microbial, antiviral, anti-oxidant, and estrogen-like activities.

Methods: Irigenin isolated from the rhizome of Belamcanda chinensis and the genus Iris showed a wide range of biological activities. Due to the huge biological potential and the therapeutic benefits of irigenin in medicine, here in the present investigation, scientific research data on irigenin has been collected from different literature sources (Science Direct, Google Scholar, PubMed, Google) and analyzed in order to know the therapeutic potential of irigenin in medicine. Scientific data on the pharmacological activities of irigenin have been collected from Science Direct, Google Scholar, PubMed, and Google databases and analyzed in the present work. The importance of different analytical techniques for the isolation and separation of irigenin has also been discussed and presented in the current work.

Results: Scientific data analysis of different research works revealed the biological importance of irigenin in medicine. Irigenin is an O-methylated isoflavone found to be present in the Belamcanda chinensis and genus Iris. Scientific data analysis revealed the biological importance of irigenin against gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation, and cardiac injury. Analytical data on irigenin revealed the importance of analytical techniques for the separation, isolation, and identification of irigenin from various biological samples.

Conclusion: Scientific data analysis of different research works revealed the biological importance and therapeutic potential of irigenin in medicine.

Keywords: Irigenin, gastric cancer, lung carcinoma, prostate cancer, breast cancer, endometrial cancer, diabetic complications, inflammation, cardiac injury.

Graphical Abstract

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Cite As

Current Cancer Therapy Reviews

Biological Activities and Therapeutic Potential of Irigenin on Gastric, Lung, Prostate, Breast, and Endometrial Cancer: Pharmacological and Analytical Aspects

Abstract

Graphical Abstract