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Current Pharmaceutical Design

Author(s): Fahad Al Ghamdi, Salma Naqvi, Fahad A. Alabassi, Sultan Alhayyani, Mirza Rafi Baig, Vikas Kumar and Firoz Anwar*

DOI: 10.2174/1381612828666220322123225

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Alterations in Clinical Characteristics of Blood Donors Post COVID-19 Recovery

Page: [981 - 992] Pages: 12

  • * (Excluding Mailing and Handling)

Abstract

Background: Corona Virus Disease-19 (COVID-19), a current worldwide pandemic is the cause of serious concern. Risk-adjusted differences in outcomes of the patients are not well characterized. Therefore, susceptibility to infection with respect to blood group, blood pressure, pulse rate, hemoglobin, age, and BMI is analyzed in this study.

Methods: Blood donors of all ages and gender, who recovered from COVID-19 infection, were selected for the study. Samples were collected from the regional laboratory and the central blood bank of Hafr al Batin, Saudi Arabia. Out of 1508 healthy blood donors, 134 had recovered from corona without any preexisting diseases.

Results: Major donors were male (85.1%). 28% of donors were in the age range of 26-35 years. O+(32.8%) donors were in majority. Systolic and diastolic blood pressure and pulse rate elevated significantly in the age group 46-55 (p<0.05) and 56-65 (p<0.001). Systolic blood pressure in males (134.13 ± 9.57) was significantly higher (p<0.05) than in females (129.35 ± 10.61). Donors with Rh+ had significantly higher systolic (p<0.05) and pulse rate (p<0.05) as compared to Rh–.

Discussion: O+ donors were found to be highly susceptible. Blood pressure, pulse rate and Hb altered with age. Males exhibited higher variation in systolic blood pressure, with the Rh+ factor playing a predominant role. Donors above 45-years of age and with a high BMI had significantly elevated blood pressure and pulse. These results are challenging or contradictory to the results of Turkish and Chinese studies where blood group A+ was more predominantly affected by the SARS-CoV-2 with the minimum infection rate in females and Rh- donors.

Conclusion: Factors like blood group, age, physical characteristics and BMI should be taken into account before initiating any therapeutic approach to obtain the best possible outcomes with minimum adverse effects from the current drugs utilized for SARS CoV-2 treatment, especially with the age group of 45 years and above.

Keywords: COVID-19, blood donors, ABO group, Rh factor, blood pressure, SARS CoV-2.

[1]
Zhou P, Yang X-L, Wang X-G, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270-3.
[PMID: 32015507]
[2]
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet 2020; 395(10223): 507-13.
[http://dx.doi.org/10.1016/S0140-6736(20)30211-7] [PMID: 32007143]
[3]
Calcagnile M, Forgez P, Iannelli A, Bucci C, Alifano M, Alifano P. Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 spike protein. Biochimie 2021; 180: 143-8.
[http://dx.doi.org/10.1016/j.biochi.2020.11.004] [PMID: 33181224]
[4]
Liumbruno GM, Franchini M. Beyond immunohaematology: The role of the ABO blood group in human diseases. Blood Transfus 2013; 11(4): 491-9.
[PMID: 24120598]
[5]
Melzer D, Perry JR, Hernandez D, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 2008; 4(5): e1000072.
[http://dx.doi.org/10.1371/journal.pgen.1000072] [PMID: 18464913]
[6]
Jing W, Zhao S, Liu J, Liu M. ABO blood groups and hepatitis B virus infection: A systematic review and meta-analysis. BMJ Open 2020; 10(1): e034114.
[http://dx.doi.org/10.1136/bmjopen-2019-034114] [PMID: 32014878]
[7]
Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. Br J Haematol 2020; 190(1): 24-7.
[http://dx.doi.org/10.1111/bjh.16797] [PMID: 32379894]
[8]
Cheng Y, Cheng G, Chui CH, et al. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA 2005; 293(12): 1450-1.
[PMID: 15784866]
[9]
Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta 2020; 509: 220-3.
[http://dx.doi.org/10.1016/j.cca.2020.06.026] [PMID: 32562665]
[10]
Chen Z, Yang S-H, Xu H, Li J-J. ABO blood group system and the coronary artery disease: An updated systematic review and meta-analysis. Sci Rep 2016; 6(1): 23250.
[http://dx.doi.org/10.1038/srep23250] [PMID: 26988722]
[11]
Tan M, Jiang X. Norovirus-host interaction: Multi-selections by human histo-blood group antigens. Trends Microbiol 2011; 19(8): 382-8.
[http://dx.doi.org/10.1016/j.tim.2011.05.007] [PMID: 21705222]
[12]
Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Rev 2015; 28(3): 801-70.
[http://dx.doi.org/10.1128/CMR.00109-14] [PMID: 26085552]
[13]
Chakrani Z, Robinson K, Taye B. Association between ABO blood groups and Helicobacter pylori infection: A meta-analysis. Sci Rep 2018; 8(1): 17604.
[http://dx.doi.org/10.1038/s41598-018-36006-x] [PMID: 30514875]
[14]
Liu J, Zhang S, Liu M, Wang Q, Shen H, Zhang Y. Distribution of ABO/Rh blood groups and their association with hepatitis B virus infection in 3.8 million Chinese adults: A population-based cross-sectional study. J Viral Hepat 2018; 25(4): 401-11.
[http://dx.doi.org/10.1111/jvh.12829] [PMID: 29193618]
[15]
Ojobor CD, Olovo CV, Onah LO, Ike AC. Prevalence and associated factors to rotavirus infection in children less than 5 years in Enugu State, Nigeria. Virusdisease 2020; 31(3): 1-7.
[http://dx.doi.org/10.1007/s13337-020-00614-x] [PMID: 32837972]
[16]
Murugananthan K, Subramaniyam S, Kumanan T, Owens L, Ketheesan N, Noordeen F. Blood group AB is associated with severe forms of dengue virus infection. Virusdisease 2018; 29(1): 103-5.
[http://dx.doi.org/10.1007/s13337-018-0426-8] [PMID: 29607366]
[17]
Tazebew B, Abitew AM, Nibret E. Prevalence and association of malaria with ABO blood group and hemoglobin levels in individuals visiting Mekaneeyesus primary hospital, Estie district, Northwest Ethiopia: A cross-sectional study. Parasitol Res 2021; 120(5): 1821-35.
[PMID: 33655352]
[18]
Göker H, Aladağ Karakulak E, Demiroğlu H, et al. The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. Turk J Med Sci 2020; 50(4): 679-83.
[http://dx.doi.org/10.3906/sag-2005-395] [PMID: 32496734]
[19]
Fan Q, Zhang W, Li B, Li D-J, Zhang J, Zhao F. Association between ABO blood group system and COVID-19 susceptibility in Wuhan. Front Cell Infect Microbiol 2020; 10: 404.
[http://dx.doi.org/10.3389/fcimb.2020.00404] [PMID: 32793517]
[20]
Wu C, Miao X, Huang L, et al. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet 2011; 44(1): 62-6.
[http://dx.doi.org/10.1038/ng.1020] [PMID: 22158540]
[21]
Guillon P, Clément M, Sébille V, et al. Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology 2008; 18(12): 1085-93.
[http://dx.doi.org/10.1093/glycob/cwn093] [PMID: 18818423]
[22]
Heggelund JE, Varrot A, Imberty A, Krengel U. Histo-blood group antigens as mediators of infections. Curr Opin Struct Biol 2017; 44: 190-200.
[http://dx.doi.org/10.1016/j.sbi.2017.04.001] [PMID: 28544984]
[23]
Anstee DJ. The relationship between blood groups and disease. Blood 2010; 115(23): 4635-43.
[http://dx.doi.org/10.1182/blood-2010-01-261859] [PMID: 20308598]
[24]
Moulds JM, Moulds JJ. Blood group associations with parasites, bacteria, and viruses. Transfus Med Rev 2000; 14(4): 302-11.
[http://dx.doi.org/10.1053/tmrv.2000.16227] [PMID: 11055075]
[25]
Abegaz SB. ABO and Rh (D) blood group distribution among blood donors: A Study of natural and computational science faculty graduating class students at Woldia university, Ethiopia. Int J Genet Mol Biol 2021; 13: 21-30.
[http://dx.doi.org/10.5897/IJGMB2020.0203]
[26]
Taha SAH, Osman MEM, Abdoelkarim EAA, et al. Individuals with a Rh-positive but not Rh-negative blood group are more vulnerable to SARS-CoV-2 infection: Demographics and trend study on COVID-19 cases in Sudan. New Microbes New Infect 2020; 38: 100763.
[http://dx.doi.org/10.1016/j.nmni.2020.100763] [PMID: 32983543]
[27]
Azcona G, Bhatt A, Davies SE, Harman S, Smith J, Wenham C. Spotlight on gender, COVID-19 and the SDGs: Will the pandemic derail hard-won progress on gender equality?. UN Women 2020.
[28]
Mahajan P, Kaushal J. Epidemic trend of COVID-19 transmission in India during lockdown-1 phase. J Community Health 2020; 45(6): 1291-300.
[http://dx.doi.org/10.1007/s10900-020-00863-3] [PMID: 32578006]
[29]
Kim EJ, Marrast L, Conigliaro J. COVID-19: Magnifying the effect of health disparities. J Gen Intern Med 2020; 35(8): 2441-2.
[http://dx.doi.org/10.1007/s11606-020-05881-4] [PMID: 32394141]
[30]
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet 2020; 395(10229): 1054-62.
[http://dx.doi.org/10.1016/S0140-6736(20)30566-3] [PMID: 32171076]
[31]
Nikolich-Zugich J, Knox KS, Rios CT, Natt B, Bhattacharya D, Fain MJ. SARS-CoV-2 and COVID-19 in older adults: What we may expect regarding pathogenesis, immune responses, and outcomes. Geroscience 2020; 42(2): 505-14.
[http://dx.doi.org/10.1007/s11357-020-00186-0] [PMID: 32274617]
[32]
Javanmard SH, Heshmat-Ghahdarijani K, Vaseghi G. Angiotensin-converting-enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blocker (ARB) use in COVID-19 prevention or treatment: A paradox. Infect Control Hosp Epidemiol 2021; 42(1): 118-9.
[http://dx.doi.org/10.1017/ice.2020.195] [PMID: 32362297]
[33]
Yano Y, Reis JP, Colangelo LA, et al. Association of blood pressure classification in young adults using the 2017 American college of cardiology/American heart association blood pressure guideline with cardiovascular events later in life. JAMA 2018; 320(17): 1774-82.
[http://dx.doi.org/10.1001/jama.2018.13551] [PMID: 30398601]
[34]
Grey E, Bratteli C, Glasser SP, et al. Reduced small artery but not large artery elasticity is an independent risk marker for cardiovascular events. Am J Hypertens 2003; 16(4): 265-9.
[http://dx.doi.org/10.1016/S0895-7061(02)03271-5] [PMID: 12670741]
[35]
Kumar S, Kumar N, Kumar A, et al. The COSEVAST Study: Unravelling the role of arterial stiffness in COVID-19 disease severity. medRxiv 2020.
[http://dx.doi.org/10.1101/2020.12.18.20248317]
[36]
Pastor-Barriuso R, Banegas JR, Damián J, Appel LJ, Guallar E. Systolic blood pressure, diastolic blood pressure, and pulse pressure: An evaluation of their joint effect on mortality. Ann Intern Med 2003; 139(9): 731-9.
[http://dx.doi.org/10.7326/0003-4819-139-9-200311040-00007] [PMID: 14597457]
[37]
Bwire GM, Paulo LS. Coronavirus disease-2019: Is fever an adequate screening for the returning travelers? Trop Med Health 2020; 48(1): 14.
[http://dx.doi.org/10.1186/s41182-020-00201-2] [PMID: 32165854]
[38]
Cunha BA. The diagnostic significance of relative bradycardia in infectious disease. Clin Microbiol Infect 2000; 6(12): 633-4.
[http://dx.doi.org/10.1046/j.1469-0691.2000.0194f.x] [PMID: 11284920]
[39]
Ikeuchi K, Saito M, Yamamoto S, Nagai H, Adachi E. Relative bradycardia in patients with mild-to-moderate coronavirus disease, Japan. Emerg Infect Dis 2020; 26(10): 2504-6.
[http://dx.doi.org/10.3201/eid2610.202648] [PMID: 32610036]
[40]
Bourdillon N, Yazdani S, Schmitt L, Millet GP. Effects of COVID-19 lockdown on heart rate variability. PLoS One 2020; 15(11): e0242303.
[http://dx.doi.org/10.1371/journal.pone.0242303] [PMID: 33180839]
[41]
Gubbi S, Nazari MA, Taieb D, Klubo-Gwiezdzinska J, Pacak K. Catecholamine physiology and its implications in patients with COVID-19. Lancet Diabetes Endocrinol 2020; 8(12): 978-86.
[http://dx.doi.org/10.1016/S2213-8587(20)30342-9] [PMID: 33128872]
[42]
Lippi G, Mattiuzzi C. Hemoglobin value may be decreased in patients with severe coronavirus disease 2019. Hematol Transfus Cell Ther 2020; 42(2): 116-7.
[http://dx.doi.org/10.1016/j.htct.2020.03.001] [PMID: 32284281]
[43]
Hemilä H, Chalker E. Vitamin C as a possible therapy for COVID-19. Infect Chemother 2020; 52(2): 222-3.
[http://dx.doi.org/10.3947/ic.2020.52.2.222] [PMID: 32410417]
[44]
He H, Qiao Y, Zhang Z, et al. Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: Prevention of liver damage induced by iron overload. Food Funct 2018; 9(10): 5390-401.
[http://dx.doi.org/10.1039/C7FO02057K] [PMID: 30272083]
[45]
Kuvibidila S, Baliga S, Chandra L, French C. The role of iron in immunity and inflammation: Implications for the response to infection. In: Kuvibidila SR, Baliga SB, Chandra LC, French CL, Eds. Diet, Immunity and Inflammation. Elsevier 2013; pp. 193-220.
[http://dx.doi.org/10.1533/9780857095749.2.193]
[46]
Taneri PE, Gómez-Ochoa SA, Llanaj E, et al. Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis. Eur J Epidemiol 2020; 35(8): 763-73.
[http://dx.doi.org/10.1007/s10654-020-00678-5] [PMID: 32816244]
[47]
Latz CA, DeCarlo C, Boitano L, et al. Blood type and outcomes in patients with COVID-19. Ann Hematol 2020; 99(9): 2113-8.
[http://dx.doi.org/10.1007/s00277-020-04169-1] [PMID: 32656591]
[48]
Thayer JF, Yamamoto SS, Brosschot JF. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol 2010; 141(2): 122-31.
[http://dx.doi.org/10.1016/j.ijcard.2009.09.543] [PMID: 19910061]
[49]
Kim H-G, Cheon E-J, Bai D-S, Lee YH, Koo B-H. Stress and heart rate variability: A meta-analysis and review of the literature. Psychiatry Investig 2018; 15(3): 235-45.
[http://dx.doi.org/10.30773/pi.2017.08.17] [PMID: 29486547]
[50]
Gómez J, Albaiceta GM, García-Clemente M, et al. Angiotensin-converting enzyme (ACE1, ACE2) gene variants are associated with COVID-19 severity depending on the hypertension status. MedRxiv 2020.
[51]
Kragholm K, Andersen MP, Gerds TA, et al. Association between male sex and outcomes of coronavirus disease 2019 (COVID19)-a Danish nationwide, register-based study. Clin Infect Dis 2021; 73(11): e4025-30.
[PMID: 32634827]
[52]
Luzi L, Radaelli MG. Influenza and obesity: Its odd relationship and the lessons for COVID-19 pandemic. Acta Diabetol 2020; 57(6): 759-64.
[http://dx.doi.org/10.1007/s00592-020-01522-8] [PMID: 32249357]
[53]
Honce R, Schultz-Cherry S. Impact of obesity on influenza A virus pathogenesis, immune response, and evolution. Front Immunol 2019; 10: 1071.
[http://dx.doi.org/10.3389/fimmu.2019.01071] [PMID: 31134099]
[54]
Ryan DH, Ravussin E, Heymsfield S. COVID-19 and the patient with obesity–the editors speak out. Obesity (Silver Spring) 2020; 28(5): 847.
[http://dx.doi.org/10.1002/oby.22808] [PMID: 32237212]
[55]
Bhatraju PK, Ghassemieh BJ, Nichols M, et al. COVID-19 in critically ill patients in the Seattle region—case series. N Engl J Med 2020; 382(21): 2012-22.
[http://dx.doi.org/10.1056/NEJMoa2004500] [PMID: 32227758]
[56]
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention. JAMA 2020; 323(13): 1239-42.
[http://dx.doi.org/10.1001/jama.2020.2648] [PMID: 32091533]
[57]
Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. MedRxiv 2020.
[http://dx.doi.org/10.1101/2020.04.08.20057794]
[58]
Simonnet A, Chetboun M, Poissy J, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus2 (SARSCoV2) requiring invasive mechanical ventilation. Obesity (Silver Spring) 2020; 28(7): 1195-9.
[http://dx.doi.org/10.1002/oby.22831] [PMID: 32271993]
[59]
Michalakis K, Ilias I. SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects. Diabetes Metab Syndr 2020; 14(4): 469-71.
[http://dx.doi.org/10.1016/j.dsx.2020.04.033] [PMID: 32387864]
[60]
Smith SM, Boppana A, Traupman JA, et al. Impaired glucose metabolism in patients with diabetes, prediabetes, and obesity is associated with severe COVID-19. J Med Virol 2021; 93(1): 409-15.
[http://dx.doi.org/10.1002/jmv.26227] [PMID: 32589756]
[61]
Radzikowska U, Ding M, Tan G, et al. Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors. Allergy 2020; 75(11): 2829-45.
[http://dx.doi.org/10.1111/all.14429] [PMID: 32496587]
[62]
Després J-P, Golay A, Sjöström L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 2005; 353(20): 2121-34.
[http://dx.doi.org/10.1056/NEJMoa044537] [PMID: 16291982]
[63]
Rychter AM, Zawada A, Ratajczak AE, Dobrowolska A. Krela-Kaźmierczak I. Should patients with obesity be more afraid of COVID-19? Obes Rev 2020; 21(9): e13083.
[http://dx.doi.org/10.1111/obr.13083] [PMID: 32583537]
[64]
Stefan N, Birkenfeld AL, Schulze MB, Ludwig DS. Obesity and impaired metabolic health in patients with COVID-19. Nat Rev Endocrinol 2020; 16(7): 341-2.
[http://dx.doi.org/10.1038/s41574-020-0364-6] [PMID: 32327737]