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Central Nervous System Agents in Medicinal Chemistry

Author(s): Elahe Karami Raviz, Fatemeh Noormand, Ali Sharifzadeh Kermani, Ali Galedari, Khadijeh Esmaeilpour, Marzieh Maneshian, Taj Pari Kalantaripour, Shahriar Dabiri and Majid Asadi-Shekaari*

DOI: 10.2174/1871524922666220314123052

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Promising Effects of Naringenin and Melatonin against Hepatic Encephalopathy Impairments Induced by Bile Duct Ligation in Male Rats

Page: [31 - 38] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

Background: Bile duct ligation (BDL) is used for evaluating the protective effects of different agents with anti-inflammatory and antioxidant properties against the liver and brain damages. Naringenin (N) and melatonin (M) are used as protectants in various models of diseases.

Aims: In the current research, the combinational effects of these well-known anti-inflammatory and antioxidants agents were investigated against cerebral injuries induced by BDL in male rats.

Methods: The animals were distributed into the following groups: Sham, BDL + Vehicle and BDL+ N + M. Neuronal damages were evaluated using biochemical, motor behavioral tasks and morphological assessments.

Results: Based on the data, BDL resulted in decreasing locomotor activity, which was reversed by N and M. Morphological study confirmed that BDL led to neurodegeneration in the cortex of the rats, and the N and M treatment preserved cortical neurons. In addition, immunohistochemical (IHC) study of the rat cortex showed that BDL resulted in increasing the activated astrocytes, and the N and M treatment reduced the number of activated cells.

Conclusion: These results obviously depicted combinational therapy with N and M to exert positive effects in the BDL rats, probably due to their synergistic anti-inflammatory and antioxidant activities.

Keywords: Bile duct ligation, naringenin, melatonin, open field, anti-oxidant, anti-inflammatory, rat.

Graphical Abstract

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