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Current Drug Safety

Author(s): Sumit Jaiswal, Sankha Shubhra Chakrabarti, Tulika Rai, Neeraj Dhameja, Atul Mohan, Vandana Yadav and Upinder Kaur*

DOI: 10.2174/1574886317666220309143913

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Pregabalin Induced Maculopapular Eruption in an Elderly Male

Page: [393 - 398] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

Background: Pregabalin is used in the treatment of neuropathic pain of various etiologies and as an adjuvant in epilepsy. Blockade of the α2δ subunit of L and N-type Ca-channels is its main mechanism of neurotropic action. Compared to other antiepileptics like phenytoin, valproate and lamotrigine, and other neuropathic pain medications such as amitriptyline and duloxetine, pregabalin has a relatively favorable safety profile and hence is a drug of choice for many geriatricians.

Case Presentation: Here we describe a case of maculopapular rash induced by pregabalin in an older man, which resolved with withdrawal of the offending drug and conservative management.

Conclusion: We have also conducted a literature review of similar cases and highlighted the clinical patterns and management strategies for pregabalin-induced skin rashes.

Keywords: Anticonvulsant, dermatology, idiosyncratic, rash, skin, Pregabalin.

Graphical Abstract

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