Recent Advancements in Strategies for Abnormal Protein Clearance in
Alzheimer's Disease

Baofeng      Gong; Wenbo      Ji; Xiaohan      Chen; Peng      Li; Wenbin      Cheng; Yuchen      Zhao; Bin      He; Jianhua      Zhuang; Jie      Gao; You      Yin
Abstract

Alzheimer's disease (AD) is an intricate neurodegenerative disease with chronic and progressive development whose typical neuropathological features encompass senile plaques and neurofibrillary tangles, respectively formed by the extracellular deposition of amyloid-beta (Aβ) and the intracellular accumulation of hyperphosphorylated tau protein in the brain, particularly in limbic and cortical regions. The pathological changes are considered to be caused by the loss of Aβ and tau protein clearance mechanisms under pathological conditions, which leads to an imbalance between the rates of clearance and production. Consequently, the main strategies for treating AD aim to reduce the production of Aβ and hyperphosphorylated tau protein in the brain, inhibit their accumulation, or accelerate their clearance. Although drugs utilizing these therapeutic strategies have been studied successively, their therapeutic effects have generally been less than ideal. Fortunately, recent advances have been made in clearance strategies for these abnormally expressed proteins, including immunotherapies and nanomedicines targeting Aβ or tau, which could represent an important breakthrough for treating AD. Here, we review recent development of the strategies for the removal of abnormal proteins and provide new ideas and methods for treating AD.
Keywords: Alzheimer’s disease, amyloid, tau, abnormal protein, clearance strategies, immunotherapy, nanomedicine.
Graphical Abstract

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Cite As
Mini-Reviews in Medicinal Chemistry

Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease

Abstract

Graphical Abstract
