Abstract
Gastric cancer (GC) is the leading cause of death and cancer mortality in the world, with poor
survival for cases with higher stages of GC. During the past decade, GC stem cells (GCSCs), a group of
cancer cells, have been the focus of significant research on cancer. GCSCs have the capability of selfrenewal
and are identified to participate in GC development, invasion, chemoresistance, and tumor relapse.
Research projects have indicated the main activities of noncoding RNAs in cellular pathways. Micro
(mi)RNAs and lncRNAs play important functions in the modulation of different cellular pathways in
the post-transcriptional form through their dysregulated expression in several cancers, including GC. In
this paper, we highlight the impact of dysregulated expression of micro- and lncRNAs and their downstream
transcripts on GCSCs. Data collection on the progression of GCSCs may be beneficial for the
introduction of new insights to the GC treatment.
Keywords:
Gastric cancer, non-coding RNAs, stem cells, cancer treatment, miRNAs, lncRNAs.
Graphical Abstract
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,
Reza Safaralizadeh*
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