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Current Organocatalysis

Author(s): Aparna Das, Ram Naresh Yadav and Bimal Krishna Banik*

DOI: 10.2174/2213337209666220126123630

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A Novel Baker’s Yeast-Mediated Microwave-Induced Reduction of Racemic 3-Keto-2-Azetidinones: Facile Entry to Optically Active Hydroxy β-Lactam Derivatives

Page: [195 - 198] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

Objective: Microwave technology, together with enzymatic catalysis, is a nature-friendly chemical synthesis method with low wastage of solvent and a good yield of the products.

Methods: Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation.

Results: In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time.

Conclusion: These hydroxy compounds are the precursors of numerous natural products of medicinal significance.

Keywords: Hydroxy β-lactams, optical activity, microwave, baker’s yeast, reduction, solvent.

Graphical Abstract

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