An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained
from Chalcone

Jaqueline   E.   Queiroz; Lucas   D.   Dias; Giuliana   M. Vila   Verde; Gilberto   L.B.   Aquino; Ademir   J.   Camargo
Abstract

A review concerning the synthesis and pharmacological properties of pyrazoles obtained from Chalcone described in the literature over the last 5 years (2016-2020) was presented and discussed. Among the synthetic approaches for pyrazoles described so far, the cyclization and acetylation method of α,β-unsaturated chalcones, and substituted hydrazine were selected and analyzed. 105 pyrazole derivatives (3-107) were evaluated as well as their pharmacological activities, namely, antineoplastic, anti-inflammatory, antioxidant, antibacterial, antifungal, antimycobacterial, antiplasmodial, Alzheimer's disease, enzymes inhibition (like acetylcholinesterase, carbonic anhydrase, and malonyl CoA decarboxylase), anticonvulsant, among others. Pyrazolic compounds are widely used in the design of the new drug with a wide spectrum of pharmacological approaches. Therefore, it is relevant to research the synthetic methods and therapeutic properties of different pyrazole derivatives.
Keywords: Synthesis, chalcones, pyrazoles, biological activities, antimicrobial, antineoplastic.
Graphical Abstract

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Cite As
Current Organic Chemistry

An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained from Chalcone

Abstract

Graphical Abstract
