Arylidenemalononitriles as Versatile Synthons in Heterocyclic Synthesis

Pannala      Padmaja; B.V.   Subba   Reddy; Vinod   G.   Ugale; Pedavenkatagari   Narayana   Reddy
Abstract

Background: Arylidenemalononitriles are valuable synthons for the construction of a variety of novel complex heterocyclic motifs, fused heterocycle derivatives, and spirocyclic compounds. They are versatile chemical intermediates and have increasing applications in industry, agriculture, medicine, and biological science.
Objective: The aim of this review is to highlight the preparation methods and reactions of arylidenemalononitriles in the synthesis of various heterocyclic compounds.
Conclusion: In this review, we have presented the application of arylidenemalononitriles to construct a variety of heterocycles. Various catalysts for the preparation of arylidnemalononitriles have been described.
Keywords: Arylidenemalononitriles, Malononitrile, Knoevenagel condensation, Multi-component reactions, Heterocyclic compounds, spirocyclic compounds.
Graphical Abstract

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Cite As
Current Organic Synthesis

Arylidenemalononitriles as Versatile Synthons in Heterocyclic Synthesis

Abstract

Graphical Abstract
