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Letters in Organic Chemistry

Author(s): Yu-Xia Liu*, Zhi-Wei Ma, Chuan-Chuan Wang, Qian Li and Wen-Peng Mai

DOI: 10.2174/1570178619666220112124054

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The Catalytic Efficiency of Isosteviol Derived Bifunctional Primary Amine-Squaramide on Michael Additions of Acetophenone to Nitroalkenes

Page: [677 - 681] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

The isosteviol derived bifunctional primary amine-squaramide organocatalysts were applied in the Michael addition between nitroalkenes and acetophenone. The conjugate addition isomers of two configurations were observed with high yields (up to 93% yield) and good enantioselectivity (up to 91% ee) at room temperature.

Keywords: Isosteviol, asymmetric catalysis, organocatalyst, squaramide, michael reaction, nitroalkenes.

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