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Letters in Organic Chemistry

Author(s): Zubiao Zheng, Daoxin Zha, Peng Cui, Caixia Ye, Lei Jin and Bingbing Han*

DOI: 10.2174/1570178619666220111122536

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Preparation of Tetrasubstituted Bis(3-indolyl)methanes from Indoles and Acetophenes Using 1,3-dibromo-5,5-dimehtylhydantoin as an Efficient Catalyst

Page: [850 - 856] Pages: 7

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Abstract

A new process that could efficiently prepare tetrasubstituted bis(3-indolyl)methanes from various indoles and acetophenones with 1,3-Dibromo-5,5-dimehtylhydantoin(DBDMH) as a catalyst was reported. The effects of catalysts, solvents, and reaction temperature were investigated. Under the optimal condition, most of the tetrasubstituted bis(3-indolyl)methanes were obtained in 90–99% yields.

Keywords: Tetrasubstituted BIMs, indoles, acetophenones, DBDMH, catalyst, bisindolylation.