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Letters in Organic Chemistry

Author(s): Min Wu, Lijia Xu, Mingwei Song, Ying Li, Yingying Wang and Hongbo Dong*

DOI: 10.2174/1570178619666220111115718

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First Total Synthesis of Isopsoralenoside

Page: [832 - 836] Pages: 5

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Abstract

The first total synthesis of the natural product iopsoralenoside, isolated from the n-butyl alcohol extract of Fructus Psoraleae (FP), was achieved in 17% yield over 7 steps. The key steps of the process were glycosylation and irradiation promoted by ultraviolet light. This synthesis provided a sufficient amount of synthesized trans- and cis-isopsoralenoside for further bioassays.

Keywords: Total synthesis, natural products, isopsoralenoside, fructus psoraleae, compounds, fabaceae.

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