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Current Organic Chemistry

Author(s): Tanzeela Qadir, Andleeb Amin, Alka Salhotra, Praveen Kumar Sharma*, Ishtiaq Jeelani and Hitoshi Abe

DOI: 10.2174/1385272826666211229144446

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Recent Advances in the Synthesis of Benzothiazole and its Derivatives

Page: [189 - 214] Pages: 26

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Abstract

Benzothiazoles have recognized pharmacophores in the field of research, predominantly in synthetic and medicinal chemistry, on account of their significant pharmaceutical properties. This important class of derivatives endows an extensive range of biological activities like anti-inflammatory, antidiabetic, anticancer, anticonvulsant, antibacterial, antiviral, antioxidant, antituberculosis, enzyme inhibitors, etc. Hence, various methodologies have been accomplished to synthesize benzothiazole compounds considering the purity, yield, and selectivity of the products. This review provides different reaction methods that are involved in the synthesis of a variety of benzothiazole derivatives.

Keywords: 2-aminothiophenol, cyclization, condensation, benzothiazoles, green chemistry, thioamides, aldehydes, nitriles.

Graphical Abstract

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