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Letters in Organic Chemistry

Author(s): Suman Swami, Rahul Shrivastava*, Neelam Sharma, Arunava Agarwala, Ved Prakash Verma and Atul Pratap Singh

DOI: 10.2174/1570178619666211220094516

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An Ultrasound-Assisted Solvent and Catalyst-Free Synthesis of Structurally Diverse Pyrazole Centered 1,5-disubstituted Tetrazoles via One-Pot Four-Component Reaction

Page: [795 - 802] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

1,5-Disubstituted tetrazoles are vital drug-like scaffolds usually encountered as valuable bioisosteres of the cis-amide bond. In this article, we reported the synthesis of some novel medicinally relevant pyrazole centered 1,5-disubstituted tetrazoles using ultrasound irradiation via a one-pot 4-C reaction from various pyrazole originated aldehyde, amine, isocyanide, and sodium azide. All the synthesized derivatives were characterized by IR, 1H NMR, 13C NMR, spectroscopic techniques, and mass analysis. This ultrasound-assisted green protocol has several advantages like mild reaction condition, high yield, catalyst and solvent-free reaction protocol, 15 minutes reaction time and easy workup.

Keywords: Ultrasound irradiation, 1, 5-disubstituted tetrazole, pyrazole, catalyst-free, solvent-free, multi-component reaction, green protocol.

Graphical Abstract

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