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Cardiovascular & Hematological Disorders-Drug Targets

Author(s): Ismail Bouadid, Ayoub Amssayef, Nadia Lahrach, Ahmed El-Haidani and Mohamed Eddouks*

DOI: 10.2174/1871529X21666211209114436

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Aqueous Extract of Brassica rapa Exerts Antihyperglycemic Activity in Streptozotocin-induced Diabetic Rats

Page: [253 - 259] Pages: 7

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Abstract

Aims: The aim of the study was to assess the antihyperglycemic effect of Brassica rapa.

Background: Brassica rapa (turnip) is used as an antidiabetic plant.

Objective: This work aimed to evaluate the effect of the aqueous extract of Brassica rapa seeds (AEBRS) on glycemia in vivo.

Methods: The effect of AEBRS (60 mg/kg) on glycemia and lipid profiles was evaluated. Besides, preliminary phytochemical analysis and the in vitro antioxidant effect were evaluated.

Results: AEBRS caused a significant reduction in blood glucose levels in diabetic rats (p<0.0001). In contrast, no significant effect was observed on lipid profiles, whereas antioxidant potential of this extract has been shown. Phytochemical analysis showed the presence of many important phytochemical families.

Conclusion: The present study shows that AEBRS has a potent antihyperglycemic ability in diabetic rats.

Keywords: Brassica rapa seeds, medicinal plant, streptozotocin, antidiabetic, phytochemistry, antioxidant activity.

Graphical Abstract

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