Abstract

Various clinical results are obtained regarding the effects of cerebellar GABA transmission on spinocerebellar ataxias. Based on animal studies, it is proposed that balanced GABAergic transmission between GABA and other neurotransmitters such as glutamate may lead to more promising results in treating such conditions.

Keywords: Gamma-aminobutyric acid, spinocerebellar ataxia, Friedreich’s ataxia, glucocorticoids, Golgi cells, cerebellum.