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Mini-Reviews in Organic Chemistry

Author(s): Samuel Attah Egu*, Efeturi Abraham Onoabedje, Uchechukwu Chris Okoro, Khalid Mohammed Khan, Abdul Hameed, Irfan Ali, Shafia Iftekhar, Eboh Monday Odin and Shahbaz Shamim

DOI: 10.2174/1570193X18666211007120708

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The Synthesis and Chemistry of Quinolinediones and their Carbocyclic Analogs

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Abstract

Quinoline-5,8-dione and naphthoquinone nuclei are very important substructures in industrial chemicals and pharmaceuticals. These compounds exhibit a wide variety of activities, including antifungal, antibacterial, antimalarial, antineoplastic, anticoagulant, anticancer, antiviral, radical scavenging, antiplatelet, trypanocidal, cytotoxic, and antineoplastic activities. Currently, several research articles on the importance of many natural and synthetic drugs containing quinolinequinone have been reported. This review covers the progress in quinolinequinone and naphthoquinone chemistry over the last five decades.

Keywords: Amination, arylation, derivatives, modifications, naphthoquinone, phenoxazines, phenothiazines, quinolinequinone, synthesis.

Graphical Abstract

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