Abstract

Background: Microwave-assisted domino cyclization reactions have attracted great interest for researchers to synthesize complex compounds in shorter times with increased yields. The domino reactions were used in various synthetic approaches and many drug deliveries in medicinal chemistry with microwave-assisted approaches.

Methods: Microwave irradiation has been applied for various domino reactions. The research related to microwave-assisted domino cyclization was reviewed and the important methodologies were collected from 2011-2021.

Results: Only those methodologies that involve microwave-assisted domino cyclization reactions during synthesis in a related manner have been reviewed. Along with some recent syntheses that are microwave-assisted regarding new heterocyclic moieties are summarized.

Conclusion: Microwave-assisted domino cyclization reactions can be employed to quickly explore and increase molecular diversity in synthetic chemistry. We hope that this review will be helpful to find out complex molecule synthesis by microwave-assisted domino cyclization reactions. This review aimed to explain the applications of microwaves for the domino reactions from 2011- 2021. In this respect, microwave-mediated methods help researchers to make helpful studies.

Keywords: Domino reaction, heterocycles, green synthesis, catalysis, microwave-assisted synthesis, microwave irradiation, one-pot reaction.

Graphical Abstract