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Current Neurovascular Research

Author(s): Chenhan Lin , Kaichuang Yang, Guoqiang Zhang and Jun Yu*

DOI: 10.2174/1567202618666210923150251

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Metformin Ameliorates Neuronal Necroptosis after Intracerebral Hemorrhage by Activating AMPK

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Abstract

Background: Intracerebral hemorrhage (ICH) is a major cause of death and disability globally. As a type of secondary injury after ICH, treatment for cell death can promote the recovery of neurological function.

Methods: Among all the cell death, neuronal necroptosis has recently been demonstrated of significance in the pathogenesis of ICH. However, the administration of drugs against necroptosis has many limitations.

Results: In the present study, we found that metformin, a first-line medication for the treatment of type 2 diabetes, can effectively inhibit neuronal necroptosis after ICH by activating the AMPK related pathway, thereby significantly improving neurological function scores and reducing brain edema.

Conclusion: These results will provide a new perspective for future research in necroptosis.

Keywords: ICH, necroptosis, metformin, AMPK, rotarod test, western blot analysis.

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