The Role of Mitochondrial Genes in Neurodegenerative Disorders

Rajesh       Kumar; Seetha       Harilal; Della    Grace Thomas    Parambi; S.K.       Kanthlal; Md    Atiar    Rahman; Athanasios       Alexiou; Gaber    El-Saber    Batiha; Bijo       Mathew
Abstract

Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.
Keywords: Alzheimer's disease, amyotrophic lateral sclerosis, mtDNA, multiple sclerosis, neurodegeneration, Parkinson's disease, stroke.
Graphical Abstract

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Cite As
Current Neuropharmacology

The Role of Mitochondrial Genes in Neurodegenerative Disorders

Abstract

Graphical Abstract
