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Mini-Reviews in Medicinal Chemistry

Author(s): Ebuka Leonard Onyeyilim*, Mercy Amarachi Ezeokonkwo, David Izuchukwu Ugwu, Chiamaka Peace Uzoewulu , Florence Uchenna Eze, Vivian Ifeoma Okonkwo, Cosmas Chinweike Eze and James Anayochukwu Ezugwu

DOI: 10.2174/1389557521666210831154935

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Carbohydrazide Analogues: A Review of Synthesis and Biological Activities

Page: [661 - 682] Pages: 22

  • * (Excluding Mailing and Handling)

Abstract

Carbohydrazides and their Schiff bases are important classes of heterocycles that are not only employed in the area of organic chemistry but also have tremendous applications in physical and inorganic chemistry. A series of potentially bioactive compounds containing carbohydrazide functionality and their hydrazone derivatives have been synthesized and screened for antibacterial, anticancer, antifungal and anti-inflammatory, etc. This brief review discloses some synthetic routes to so many reported carbohydrazides, their Schiff bases, their biological activities, and their structure-activity relationship.

Keywords: Carbohydrazide, schiff bases, hydrazone, hydrazinolysis, biological activities, structure-activity relationship.

Graphical Abstract

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