Letters in Organic Chemistry

Author(s): Dau Xuan Duc* and Nguyen Van Quoc

DOI: 10.2174/1570178618666210820101129

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Microwave-assisted, Copper-free Sonogashira Coupling Between Aryl Halides and Terminal Alkynes Using Recyclable Ionic Liquid and Catalyst

Page: [28 - 33] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

An efficient method for the Sonogashira coupling reaction between aryl halides and terminal alkynes has been developed. The reaction was performed in ionic liquid 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim][BF4]) under microwave irradiation. High yields of products were obtained in a very short reaction time. Moreover, the medium and catalyst could be recovered and reused three times without considerable decrease in reaction yields.

Keywords: Coupling reaction, terminal alkynes, ionic liquid, microwave, trimethylsillylacetylene, iodide.