Author(s): Nitishkumar S. Kaminwar, Sunil U. Tekale, Srinivas L. Nakkalwar and Rajendra P. Pawar*
Page: [945 - 949] Pages: 5
* (Excluding Mailing and Handling)
Synthesis of isoxazole structural heterocyclic compounds is important due to their wide range of biological activities. In the present article, we report a convenient and easy method for the synthesis of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-ones by the one-pot three-component reaction of aldehydes, β-keto ester, and hydroxylamine hydrochloride catalyzed by sulfated tin oxide as a heterogeneous catalyst.
Keywords: Isoxazol-5(4H)-one, STO, aldehyde, β-keto ester, hydroxylamine hydrochloride, heterogeneous catalyst.
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