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Current Organic Synthesis

Author(s): Estibaliz Sansinenea and Aurelio Ortiz*

DOI: 10.2174/1570179418666210728145206

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Asymmetric Organocatalytic Syntheses of Bioactive Compounds

Page: [148 - 165] Pages: 18

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Abstract

Background: The total syntheses of complex natural products have evolved to include new methodologies to save time, simplifying the form to achieve these natural compounds.

Objectives: In this review, we have described the asymmetric synthesis of different natural products and biologically active compounds of the last ten years until the current day.

Results: An asymmetric organocatalytic reaction is a key to generate stereoselectively the main structure with the required stereochemistry.

Conclusion: Even more remarkable, the organocatalytic cascade reactions, which are carried out with high stereoselectivity, as well as a possible approximation of the organocatalysts activation with substrates are also described.

Keywords: Organocatalysis, organocatalytic process, organocatalytic cascade reactions, asymmetric synthesis, natural products, stereoselectivity, catalyst.

Graphical Abstract

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