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Current Analytical Chemistry

Author(s): Quanxia Lyu, Shu Gong, Jennifer M. Dyson and Wenlong Cheng*

DOI: 10.2174/1573411017666210706154521

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Soft, Disruptive and Wearable Electrochemical Biosensors

Page: [689 - 704] Pages: 16

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Abstract

Background: Soft wearable electrochemical biosensors are attracting increasing attention over the past several years due to their potential for non-invasive personalized health monitoring in real-time and in-situ.

Objective: Herein, we cover the design, fabrication, and applications of soft electrochemical sensing systems. Firstly, we describe key design requirements for fabricating the mechanically compliant electrochemical biosensors. This is followed by a narration of typical sensor configurations and the detecting methodologies. Next, on-body soft electrochemical biosensing and cell/tissue-based “wearable” sensing applications are summarized. Detection of key biochemical markers, including metabolites (glucose, lactate, uric acid and ethanol), electrolytes (Na+ and K+), nutrients (vitamin C), hormones (cortisol) and proteins (TNF-α), as well as cellular signalling molecules (nitric oxide, hydrogen peroxide and serotonin), is the focus of the discussion in this review.

Conclusion: We conclude the review with discussions on future opportunities and challenges of the soft and wearable electrochemical biosensors.

Keywords: Soft wearable electronics, biosensors, nanomaterials, stretchable, electrochemistry, review.

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