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Mini-Reviews in Organic Chemistry

Author(s): Sunil Tekale, Vishnu Gore, Pravin Kendrekar, Shivaji Thore, László Kótai and Rajendra Pawar*

DOI: 10.2174/1570193X18666210629103117

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COVID-19 Global Pandemic Fight by Drugs: A Mini-Review on Hope and Hype

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Abstract

Coronavirus disease 2019 (Covid-19), a serious disease caused by the Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2), was firstly identified in the city of Wuhan of China in December 2019, which then spread and became a global issue due to its high transmission rate. To date, the outbreak of COVID-19 has resulted in infection to 230,868,745 people and the death of 4,732,669 patients. It has paralyzed the economy of all the countries worldwide. Considering the possible mutations of SARS-CoV-2, the current medical emergency requires a longer time for drug design and vaccine development. Drug repurposing is a promising option for potent therapeutics against the pandemic. The present review encompasses various drugs or appropriate combinations of already FDA-approved antimalarial, antiviral, anticancer, anti-inflammatory, and antibiotic therapeutic candidates for use in the clinical trials as a ray of hope against COVID-19. It is expected to deliver better clinical and laboratory outcomes of drugs as a prevention strategy for the eradication of the disease.

Keywords: COVID-19, SARS, CoV-2, drugs, global, pandemic, MERS.

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