Abstract

The development of simple, atom-economical, and sustainable methodologies for the construction of various functional molecules from easily available substrates has been of great interest in synthetic chemistry. N,N-dimethylformamide (DMF) is an inexpensive, abundant solvent and industrial raw material, and it is considered as an effective polar solvent and also as a versatile reagent in synthetic transformations. During the past few decades, many significant and attractive achievements have been made in the fields of DMF as a reactant. The mini-review will mainly summarize recent advance in the applicants of DMF as a multipurpose building block in synthetic reactions.

Keywords: N, N-dimethylformamide, DMF, building block, organic solvent, versatile reactant, synthetic transformation, synthetic chemistry.

Graphical Abstract