Abstract

Heterocycles are very important scaffolds since many of them exhibit building blocks properties and good biological activities. Various chemical methods have been utilized for their synthesis and out of them, the environmentally benign approaches are highly demanding in view of the importance of green chemistry.

There are vast pieces of literature available on sustainable and multi-component synthetic approaches, but it is difficult for a researcher to keep up with research. Therefore, a review article in sustainable and multi-component synthesis of heterocycle was highly required. Herein, we have compiled the work of literatures related to multi-component reaction under solvent free condition, ultrasound assisted, water or ionic liquid mediated conditions.

Keywords: Heterocycle, multi-component, nitrogen, green approach, water, ultrasound assisted.