Generic placeholder image

Current Organic Synthesis

Author(s): Fahimeh Abedinifar, Mohammad Mahdavi*, Mehdi Asadi , Haleh Hamedifar , Samira Ansari* and Bagher Larijani

DOI: 10.2174/1566524021666210614141628

DownloadDownload PDF Flyer Cite As
Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies

Page: [761 - 789] Pages: 29

  • * (Excluding Mailing and Handling)

Abstract

Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.

Keywords: Azaarenes, pharmaceutical, C-H functionalization, alkenylation, oxidative, cyclization.

Graphical Abstract