Abstract

Background: The impact of personalized medicine is potentially enormous, but the genetic results are often difficult to integrate into health settings. A number of research studies are emerging to aid in translating pharmacogenomics into clinical practice.

Objective: We aimed to create a standardized process to guide the implementation of dose adjustment recommendations into the electronic health record (EHR).

Materials and Methods: Monographs were created for selected drug-gene pairs, allowing for a standardized review of available evidence. A scoring template was developed to assess whether the evidence presented in the drug monograph qualified the mentioned drug-gene pair for Clinical Decision Support (CDS) within the EHR.

Results: Of nine medications reviewed, only one drug-gene pair qualified for a CDS proposal to the institution’s governing pharmacogenomics committee.

Conclusion: This project resulted in the development of a standard process for reviewing pharmacogenomics- related literature, allowing for more CDS proposals to be accepted.

Keywords: Pharmacogenomics, Clinical Decision Support (CDS), primary literature, standardized review, drug-gene monographs, psychotropic.

Graphical Abstract