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Letters in Organic Chemistry

Author(s): Asma K. Alshamari, Mahmoud A. Al-Qudah*, Fedaa Hamadeh, Lo’ay A. Al-Momani and Sultan T. Abu-Orabi

DOI: 10.2174/1570178618666210531095246

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Synthesis, Characterization, Antimicrobial and Antioxidant Activities of 1,2,4-triazolyl-isoxazole Moieties via Dehydration Reactions of Carbohydrazides

Page: [228 - 235] Pages: 8

  • * (Excluding Mailing and Handling)

Abstract

For the reason of distinct place in the field of medicinal and pharmaceutical chemistry of 1,2,4-triazole derivatives, a new class of fused 1,2,4-triazolyl-isoxazole moieties was prepared from 3- (2,4,6-trimethoxyphenyl)isoxazolo-4,5-bis[carbonyl-(4̍-phenyl) thiosemicarbazide via dehydration reactions of carbohydrazides by using the appropriate chemical reagents. The structures of the compounds were elucidated by both elemental and spectral (IR, NMR and MS) analyses. The in vitro antioxidant activity of the new compounds was determined by free radical scavenging and metal chelating activity. All the synthesized compounds showed good activity according to free radical scavenging and metal chelating activity compared with standards. The new compounds were screened in vitro antibacterial activity against three gram-positive bacteria and three gram-negative bacteria.

Keywords: 1, 2, 4-triazolyl-isoxazole, 1, 3-dipolar cycloaddition, carbohydrazide, dehydration reactions, antibacterial activity, antioxidant activity, radical scavenging, metal chelating activity.

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