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Mini-Reviews in Organic Chemistry

Author(s): Chanchal Singh, Rajnish Kumar*, Avijit Mazumder, Salahuddin, Ajay Kumar, Rakesh Sahu, Shivali Mishra and Mohd. Mustaqeem Abdullah

DOI: 10.2174/1570193X18666210308145703

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Benzothiazole: Synthetic Strategies, Biological Potential, and Interactions with Targets

Page: [242 - 256] Pages: 15

  • * (Excluding Mailing and Handling)

Abstract

Benzothiazole is a heterocyclic compound that contains a benzene ring fused with a fivemember 1,3-thiazole ring. Several types of research have established its potential as an antimicrobial agent, anticancer agent, anti-epileptic agent, antiviral agent, etc. Nowadays, various effective drugs utilize the hybridization of two or more pharmacophores in a single-molecule for synergizing its pharmacological action or to interact with more than one target or to reduce the side effects associated with it. In this article, various strategies for the synthesis of different pharmacologically active hybrid compounds containing benzothiazole with different substituents are highlighted. Apart from presenting the synthesis strategies, the article also highlights various pharmacological actions and molecular interactions with different biological molecules of the potential drugs containing benzothiazole.

Keywords: Benzothiazole, biological actions, molecular interactions, benzene ring fused, thiazole ring, natural compounds.

Graphical Abstract

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