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Current Pharmaceutical Analysis

Author(s): Wafaa Waleed Al-Qaysi*, Mohammad K. Hammood and Eqbal Naji Tawfeeq

DOI: 10.2174/1573412917666210303114759

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Analytical Methods for the Identification of Pigments in Tattoo Inks and Some of Their Physiological Side Effects: A Review

Page: [161 - 175] Pages: 15

  • * (Excluding Mailing and Handling)

Abstract

In this review, numerous analytical methods to distinguish pigments in tattoo, paint, and ink items are discussed. The selection of a method was dependent upon the purpose, e.g., quantification or identification of pigments. The introductory part of this review focuses on describing the importance of setting up a pigment-associated safety profile. The formation of different degradation chemical substances as well as impurity trends can be indicated through the chemical investigation of pigments in tattoo products. It is noteworthy that pigment recognition in tattoo inks can work as a preliminary method to identify the pigments in a patient's tattoo before being removed by laser therapy. Contrary to the study of banned pigments, the identification process usually requires only a few indication substances for positive dyes. In general, tattoo pigments are almost insoluble in aqueous solutions, and many organic solvents and various pigment analyses have been conducted. It is proposed that in the future, laboratories concerned with tattoo substance analysis should have access to extensive pigment specifications and spectroscopic databases. The most important and recent physiological side effects of tattooing have been discussed in this review.

Keywords: Tattoo ink, analytical methods, pigments, heavy metals, side effects, physiological effects.

Graphical Abstract

[1]
Europe, C. On requirements and criteria for the safety of tattoos and permanent make-up, Resolution ResAP, 2008. 1 (superseding Resolution ResAP(2003)2 on tattoos and permanent make-up)
[2]
Laux, P.; Tralau, T.; Tentschert, J. A medical-toxicological view of tattooing.Lancet; (London, England), 2016, 387, pp. 395-402.
[http://dx.doi.org/10.1016/S0140 6736(15)60215-X]
[3]
Roberti, J.W.; Storch, E.A. Psychosocial adjustment of college students with tattoos and piercings. J. Coll. Couns., 2005, 8, 14-19.
[http://dx.doi.org/10.1002/j.2161-1882.2005.tb00068.x]
[4]
Krutak, L. The cultural heritage of tattooing: a brief history. Curr. Probl. Dermatol., 2015, 48, 1-5.
[http://dx.doi.org/10.1159/000369174] [PMID: 25833618]
[5]
Hussein, H.J. Determination of some heavy Metals in tattoo Stickers in Children sweets available in local markets. Iraqi J. Market Res. Consumer Protect., 2020, 12, 1.
[http://dx.doi.org/10.28936/jmracpc]
[6]
Tsokos, M.; Cains, G.; Byard, R. The forensic and cultural implications of tattooing. Forensic Pathol. Rev., 2008, 5, 197-218.
[7]
Kossida, T.; Rigopoulos, D.; Katsambas, A.; Anderson, R.R. Optimal tattoo removal in a single laser session based on the method of repeated exposures. J. Am. Acad. Dermatol., 2012, 66(2), 271-277.
[http://dx.doi.org/10.1016/j.jaad.2011.07.024] [PMID: 22036610]
[8]
Sand by-Møller, J.; Poulsen, T.; Wulf, H.C. Epidermal thickness at different body siter: Relationship to age, gender, pigmentation, blood content, skin type, and smoking habits. Acta Derm. Venereol., 2003, 83, 410-413.
[http://dx.doi.org/10.1080/00015550310015419] [PMID: 14690333]
[9]
Baan, R. A. Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: recent evaluations by an IARC monographs working group. Inhalation Toxicology, 2007, 19(sup1), 213-228.
[10]
Ghose, A.; Sayeed, A.A.; Hossain, A.; Rahman, R.; Faiz, A.; Haque, G. Mass barium carbonate poisoning with fatal outcome, lessons learned: a case series. Cases J., 2009, 2, 9327.
[http://dx.doi.org/10.1186/1757-1626-2-9327] [PMID: 20066057]
[11]
Prior, G. Tattoo inks: legislation, pigments, metals and chemical analysis. Curr Probl Dermatol; Basel:Karge Berlin; , 2015, 48, pp. 152-157.
[http://dx.doi.org/10.1159/000369196]
[12]
Tighe, M.; Libby, D.; Dorn, S.; Hosmer, J.; Peaslee, G. A survey of metals found in tattoo inks. J. Environ. Prot. (Irvine Calif.), 2017, 8, 1243-1253.
[http://dx.doi.org/10.4236/jep.2017.811077]
[13]
Tchounwou, P.B.; Yedjou, C.G.; Patlolla, A.K.; Sutton, D.J. Heavy metal toxicity and the environment; Molecular, Clinical and Environmental Toxicology;, 2012, pp. 133-164.
[14]
Katz, L. Regulation of tattoo inks in the US. Free University of Berlin. Bundesinstitut fur Risikobewertung (BfR-Symposium), 2013, 14.
[15]
McGovern, V. Metal toxicity: tattoos: safe symbols? Environ. Health Perspect., 2005, 113(9)
[http://dx.doi.org/10.1289/ehp.113-a590a]
[16]
Pamela, M.; LeBlanc, M.P.H.; Katherine, A. Tattoo ink–related infections - awareness, diagnosis, reporting, and prevention. N. Engl. J. Med., 2012, 1-3.
[http://dx.doi.org/10.1056/NEJMp1206063]
[17]
Jacoben, E.; Tonnring, K.; Pedersen, E.; Serup, J.; Nielsen, E. (Chemical substances in tattoo ink. survey of chemical substances in consumer products no. 116) Miljøstyrelsen: copenhagen 2012.
[18]
NicDaeid. N.; Miranda, MD forensic analysis of tattoos and tattoo inks. Anal. Bioanal. Chem., 2016, 408(6), 247-6248.
[19]
Forte, G.; Petrucci, F.; Cristaudo, A.; Bocca, B. Market survey on toxic metals contained in tattoo inks. Sci. Total Environ., 2009, 407(23), 5997-6002.
[http://dx.doi.org/10.1016/j.scitotenv.2009.08.034] [PMID: 19766292]
[20]
Poon, K.; Dadour, I.; McKinley, A. In situ chemical analysis of modern organic tattooing inks and pigments by micro-Raman spectroscopy. J. Raman Spectrosc., 2008, 39, 1227-1237.
[http://dx.doi.org/10.1002/jrs.1973]
[21]
Høgsberg, T.; Loeschner, K.; Löf, D.; Serup, J. Tattoo inks in general usage contain nanoparticles. Br. J. Dermatol., 2011, 165, 1210-1218.
[http://dx.doi.org/10.1111/j.1365 2133.2011.10561.x]
[22]
Golka, K.; Kopps, S.; Myslak, Z.W. Carcinogenicity of azo colorants: influence of solubility and bioavailability. Toxicol. Lett., 2004, 151(1), 203-210.
[http://dx.doi.org/10.1016/j.toxlet.2003.11.016] [PMID: 15177655]
[23]
Athar, M.; Farrukh, S. Article on undesirable effects of different chemicals used in tattoo inks. MOJ Toxicol., 2019, 5(2), 62-64.
[24]
Vandenabeele, P.; Verpoort, F.; Moens, L. Non-destructive analysis of paintings using Fourier transform Raman spectroscopy with fibre optics. J. Raman Spectrosc., 2001, 32, 263-269.
[http://dx.doi.org/10.1002/jrs.691]
[25]
Eghbali, K.; Mousavi, Z.; Ziarati, P. Determination of heavy metals in tattoo ink. Biosci. Biotechnol. Res. Asia, 2014, 11(2), 941-946.
[http://dx.doi.org/10.13005/bbra/1363]
[26]
Schreiver, I.; Hutzler, C.; Andree, S.; Laux, P.; Luch, A. Identification and hazard prediction of tattoo pigments by means of pyrolysis-gas chromatography/mass spectrometry. Arch. Toxicol., 2016, 90(7), 1639-1650.
[http://dx.doi.org/10.1007/s00204-016-1739-2] [PMID: 27209489]
[27]
Forte, G.; Petrucci, F.; Cristaudo, A.; Bocca, B. Quantification of sensitizing metals in tattooing pigments by SF-ICP-MS technique. Open Chem. Biomed. Methods. J., 2009, 2, 42-47.
[http://dx.doi.org/10.2174/1875038900902020042]
[28]
Yashim, Z.I. Determination of Heavy Metals in Black Tattoo Inks Sold Within Zaria FUW Trends in Science & Technology Journal, 2017, 2(1A), 122-125.www.ftstjournal.com e-ISSN: 24085162; p-ISSN: 20485170
[29]
Manso, M.; Pessanha, S.; Guerra, M.; Reinholz, U.; Afonso, C.; Radtke, M.; Lourenço, H.; Carvalho, M.L.; Buzanich, A.G. Assessment of toxic metals and hazardous substances in tattoo inks using Sy-XRF, AAS, and raman spectroscopy Bio. Trace Elem. Res., 2019, 187(2), 596-607.
[http://dx.doi.org/10.1007/s12011-018-1406-y]
[30]
Salau, I.O.; Maitera, O.N.; Hassan, I. Determination of heavy metal contents in eyeliners, lipsticks and black tattoo inks (local and foreign) sold in adamawa state. IDOSR JCAS., 2018, 3(1), 12-24.
[31]
EPA. Envinomental Protection Authority. Guidliven. for talloo and permanent makeup Substances. Direct nicez; New Zealand EPA, Gobierno de, 2012.
[32]
Bhakti, R.; Petigara, B. Separation and identification of pigments found in permanent cosmetic/tattoo inks using reversed-phase high performance liquid chromatography and photodiode array detection. Abstracts of the 230th ACS National Meeting, August 28, 2005.
[33]
Cui, Y.; Spann, A.P.; Couch, L.H.; Gopee, N.V.; Evans, F.E.; Churchwell, M.I.; Williams, L.D.; Doerge, D.R.; Howard, P.C. Photodecomposition of Pigment Yellow 74, a pigment used in tattoo inks. Photochem. Photobiol., 2004, 80(2), 175-184.
[http://dx.doi.org/10.1562/2004-04-06-RA-136.1] [PMID: 15362942]
[34]
Engel, E.; Santarelli, F.; Vasold, R.; Ulrich, H.; Maisch, T.; König, B.; Landthaler, M.; Gopee, N.V.; Howard, P.C.; Bäumler, W. Establishment of an extraction method for the recovery of tattoo pigments from human skin using HPLC diode array detector technology. Anal. Chem., 2006, 78(18), 6440-6447.
[http://dx.doi.org/10.1021/ac0607461] [PMID: 16970319]
[35]
Skoog, D.A.; Holler, F.J.; Nieman, T.A. Principles of Instrumental Analysis, 5th ed; Harcourt Brace College Publishers: Philadelphia, PA, 1998, Ch.12, pp. 272-294.
[36]
Curtis, T. Chemical Analysis of Tattoo Inks to Aid in the Identification of Highly Decomposed Remains. thesis, 2017.
[37]
Galavis, P.E.; Sanfilippo, N.J.; Das, I.J. Glamour, expression, and consequences of tattoos in radiation treatment. PLoS ONE, 2019, 14(8), e220030.
[http://dx.doi.org/10.1371/journal.pone.0220030]
[38]
Schreiver, I.; Hesse, B.; Seim, C.; Castillo-Michel, H.; Anklamm, L.; Villanova, J.; Dreiack, N.; Lagrange, A.; Penning, R.; De Cuyper, C.; Tucoulou, R.; Bäumler, W.; Cotte, M.; Luch, A. Distribution of nickel and chromium containing particles from tattoo needle wear in humans and its possible impact on allergic reactions. Part. Fibre Toxicol., 2019, 16(1), 33.
[http://dx.doi.org/10.1186/s12989-019-0317-1] [PMID: 31451117]
[39]
Bäumler, W.; Eibler, E.T.; Hohenleutner, U.; Sens, B.; Sauer, J.; Landthaler, M. Q-switch laser and tattoo pigments: first results of the chemical and photophysical analysis of 41 compounds. Lasers Surg. Med., 2000, 26(1), 13-21.
[http://dx.doi.org/10.1002/(SICI)1096-9101(2000)26:1<13::AIDLSM4>3.0.CO;2-S] [PMID: 10636999]
[40]
Arl, M.; Jos’e Nogueira, D.; K¨oerich, J.S.; Justino, N.M.; Vicentini, D.S.; Matias, W.G. Tattoo inks: characterization and in vivo and in vitro toxicological evaluation. J. Hazard. Mater., 2018. (October)
[http://dx.doi.org/10.1016/j.jhazmat.2018.10.072] [PMID: 30388639]
[41]
Vila, A.; Garcia, F.J. Analysis of the chemical composition of red pigments and inks for the characterization and differentiation of contemporary prints. Anal. Lett., 2012, 45, 1274-1285.
[http://dx.doi.org/10.1080/00032719.2012.673100]
[42]
Haynes, C.L.; McFarland, D.A.; Van Duyne, R.P. Surface-enhanced Raman spectroscopy. Anal. Chem., 2005, 77, 338A-346A.
[http://dx.doi.org/10.1021/ac053456d]
[43]
Raman, C.V.; Krishnan, K.S. The production of new radiations by light scattering-Part I. Proc. R. Soc. Lond., A Contain. Pap. Math. Phys. Character, 1929, 122(789), 23-35.
[http://dx.doi.org/10.1098/rspa.1929.0002]
[44]
Cinotti, E.; Labeille, B.; Boukenter, A.; Ouerdane, Y.; Cambazard, F.; Perrot, J.L. Characterization of coal tattoos by Raman spectroscopy. Skin Res. Technol., 2015, 21(4), 511-512.
[http://dx.doi.org/10.1111/srt.12221] [PMID: 25788244]
[45]
Yakes, B.J.; Michael, T.J.; Perez-Gonzalez, M.; Harp, B.P. Investigation of tattoo pigments by Raman spectroscopy. J. Raman Spectrosc., 2017, 48, 736-743.
[http://dx.doi.org/10.1002/jrs.5095]
[46]
Carlsen, K.H.; Køcks, M.; Sepehri, M.; Serup, J. Allergic reactions in red tattoos: Raman spectroscopy for ‘fingerprint’ detection of chemical risk spectra in tattooed skin and culprit tattoo inks. Skin Res. Technol., 2016, 0, 1-10.
[http://dx.doi.org/10.1111/srt.12287]
[47]
Binnig, G.; Quate, C.F.; Gerber, C. Atomic force microscope. Phys. Rev. Lett., 1986, 56(9), 930-933.
[http://dx.doi.org/10.1103/PhysRevLett.56.930] [PMID: 10033323]
[48]
Gross, L.; Mohn, F.; Moll, N.; Schuler, B.; Criado, A.; Guitián, E.; Peña, D.; Gourdon, A.; Meyer, G. Bond-order discrimination by atomic force microscopy. Science, 2012, 337(6100), 1326-1329.
[http://dx.doi.org/10.1126/science.1225621] [PMID: 22984067]
[49]
Butt, H-J.; Cappella, B.; Kappl, M. Force measurements with the atomic force microscope: Technique, interpretation and applications. Surf. Sci. Rep., 2005, 59, 1-152.
[http://dx.doi.org/10.1016/j.surfrep.2005.08.003]
[50]
Svensson, R.B.; Hassenkam, T.; Grant, C.A.; Magnusson, S.P. tensile properties of human collagen fibrils and fascicles are insensitive to environmental salts. Biophys. J., 2010, 99, 4020-4027.
[http://dx.doi.org/10.1016/j.bpj.2010.11.018]
[51]
Brockwell, D. Force denaturation of proteins – an unfolding story J. Curr. Nanosci., 2007, 3, 3-15.
[http://dx.doi.org/10.2174/1573413710703010003]
[52]
Grant, C.A.; Twigg, P.C.; Tobin, D.J. Nano-scale observations of tattoo pigments in skin by atomic force microscopy.Curr Probl Dermatol; Karger: Basel; , 2015, 48, pp. 97-102.
[http://dx.doi.org/10.1159/000369187]
[53]
Grant, C.A.; Twigg, P.C.; Baker, R.; Tobin, D.J. Tattoo ink nanoparticles in skin tissue and fibroblasts. Beilstein J. Nanotechnol., 2015, 6, 1183-1191.
[http://dx.doi.org/10.3762/bjnano.6.120] [PMID: 26171294]
[54]
Timko, A.L.; Miller, C.H.; Johnson, F.B.; Ross, E. In vitro quantitative chemical analysis of tattoo pigments. Arch. Dermatol., 2001, 137(2), 143-147.
[PMID: 11176685]
[55]
Hauri, U. Inks for tattoos and permanent make-up—pigments, preservatives, aromatic amines, polyaromatic hydrocarbons and nitrosamines. Swiss National Investigation Campaign, 2014.kantonslabor.bs.ch/dms/kantonslabor/download/berichte/berichte-2014/Tattoo_PMU_2014_EN-UK-/Tattoo_PMU_ 2014_EN%28UK%29.pdf
[56]
Hauri, U. Tinten für Tattoo und PMU/organische Pigmente, Aromatische Amine, nitrosamine, Konservierungsmittel und weitere Verunreinigungen. 2011.http://www.gesundheitsschutz.bs.ch/konsum-umwelt/berichte. html Article available in German only.1 Feb 2016
[57]
Niederer, M.; Hauri, U.; Kroll, L.; Hohl, C. Identification of organic pigments in tattoo inks and permanent make-up using laser desorption ionisation mass spectrometry [version 2; referees: 2 approved] 2018, 6(2034), 1-14.
[http://dx.doi.org/10.12688/f1000research.13035.2]
[58]
Lopes da Silva, E. El Tatuaje en el mundo y su relación con la religión. RUTA. Número, 2015, 6, 1-9.
[59]
Bäumler, W. Tattoos and their potential health consequences. Dtsch. Arztebl. Int., 2016, 113(40), 663-664.
[PMID: 27788746]
[60]
Oanţă, A.; Irimie, M. Tinea on a Tattoo. Acta Dermatovenerol. Croat., 2016, 24(3), 223-224.
[PMID: 27663926]
[61]
Schwob, E.; Kluger, N. Tinea corporis within recent tattoos. Ann. Dermatol. Venereol., 2020, 9S0151-9638(20), 30242-30248.
[http://dx.doi.org/10.1016/j.annder.2020.04.019]
[62]
Begolli Gerqari, A.; Ferizi, M.; Kotori, M.; Daka, A.; Hapciu, S.; Begolli, I.; Begolli, M.; Gerqari, I. Activation of Herpes Simplex Infection after Tattoo. Acta Dermatovenerol. Croat., 2018, 26(1), 75-76.
[PMID: 29782308]
[63]
Carney, K.; Dhalla, S.; Aytaman, A.; Tenner, C.T.; Francois, F. Association of tattooing and hepatitis C virus infection: a multicenter case-control study. Hepatology, 2013, 57(6), 2117-2123.
[http://dx.doi.org/10.1002/hep.26245] [PMID: 23315899]
[64]
Yang, S.; Wang, D.; Zhang, Y.; Yu, C.; Ren, J.; Xu, K.; Deng, M.; Tian, G.; Ding, C.; Cao, Q.; Li, Y.; Chen, P.; Xie, T.; Wang, C.; Wang, B.; Yao, J.; Threapleton, D.; Mao, C.; Ruan, B.; Li, L. Transmission of hepatitis B and C virus infection through body piercing: a systematic review and meta-analysis. Medicine (Baltimore), 2015, 94(47), e1893.
[http://dx.doi.org/10.1097/MD.0000000000001893] [PMID: 26632685]
[65]
Sankaranantham, M. HIV transmission through tattoos. HIV Current Research, 2017, 2(2), 1000124.
[http://dx.doi.org/10.4172/2572-0805.1000124]
[66]
Wittkopf, D.; Hendricks, L.; Tague, A. HIV/AIDS and Tattoos: A Deadly Link. J. AIDS Clin. Res., 2017, 8(11), 746.
[http://dx.doi.org/10.4172/2155-6113.1000746]
[67]
Kwon, Y.; Lee, D.G. Considering an approach for assessing the relevance of Tattoo-associated health risk from an overall toxicological perspective. Iran. J. Public Health, 2018, 47(5), 755-756.
[PMID: 29922620]
[68]
Jungmann, S.; Laux, P.; Bauer, T.T.; Jungnickel, H.; Schönfeld, N.; Luch, A. From the tattoo studio to the emergency room. Dtsch. Arztebl. Int., 2016, 113(40), 672-675.
[http://dx.doi.org/10.3238/arztebl.2016.0672] [PMID: 27788748]
[69]
Wenzel, S.M.; Rittmann, I.; Landthaler, M.; Bäumler, W. Adverse reactions after tattooing: review of the literature and comparison to results of a survey. Dermatology, 2013, 226(2), 138-147.
[http://dx.doi.org/10.1159/000346943] [PMID: 23689478]
[70]
Serup, J.; Hutton Carlsen, K.; Dommershausen, N.; Sepehri, M.; Hesse, B.; Seim, C.; Luch, A.; Schreiver, I. Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies. Contact Dermatitis, 2020, 82, 73-82.
[http://dx.doi.org/10.1111/cod.13423]
[71]
van der Bent, S.A.S.; de Winter, R.W.; Wolkerstorfer, A.; Rustemeyer, T. Red tattoo reactions, a prospective cohort on clinical aspects. J. Eur. Acad. Dermatol. Venereol., 2019, 33(10), e384-e386.
[PMID: 31081151]
[72]
Thum, C.K.; Biswas, A. Inflammatory complications related to tattooing: a histopathological approach based on pattern analysis. Am. J. Dermatopathol., 2015, 37(1), 54-66.
[http://dx.doi.org/10.1097/DAD.0b013e3182974558] [PMID: 23974222]
[73]
Hutton Carlsen, K.; Serup, J. Patients with tattoo reactions have reduced quality of life and suffer from itch: Dermatology life quality index and itch severity score measurements. Skin Res. Technol., 2015, 21(1), 101-107.
[http://dx.doi.org/10.1111/srt.12164] [PMID: 25066612]
[74]
Brady, B.G.; Gold, H.; Leger, E.A.; Leger, M.C. Self-reported adverse tattoo reactions: a New York City Central Park study. Contact Dermat., 2015, 73(2), 91-99.
[http://dx.doi.org/10.1111/cod.12425] [PMID: 26016445]
[75]
Islam, P.S.; Chang, C.; Selmi, C.; Generali, E.; Huntley, A.; Teuber, S.S.; Gershwin, M.E. Medical complications of tattoos: a comprehensive review. Clin. Rev. Allergy Immunol., 2016, 50(2), 273-286.
[http://dx.doi.org/10.1007/s12016-016-8532-0] [PMID: 26940693]
[76]
Lim, H-H.; Shin, H-S. Identification and Quantification of Phthalates, PAHs, Amines, Phenols, and Metals in Tattoo. Bull. Korean Chem. Soc., 2015, 36, 2039-2050.
[http://dx.doi.org/10.1002/bkcs.10395]
[77]
Bil, W.; van der Bent, S.A.S.; Spiekstra, S.W.; Nazmi, K.; Rustemeyer, T.; Gibbs, S. Comparison of the skin sensitization potential of 3 red and 2 black tattoo inks using interleukin-18 as a biomarker in a reconstructed human skin model. Contact Dermat., 2018, 79(6), 336-345.
[http://dx.doi.org/10.1111/cod.13092] [PMID: 30136287]
[78]
Arl, M.; Nogueira, D.J.; Schveitzer Köerich, J.; Mottim Justino, N.; Schulz Vicentini, D.; Gerson Matias, W. Tattoo inks: Characterization and in vivo and in vitro toxicological evaluation. J. Hazard. Mater., 2019, 364, 548-561.
[http://dx.doi.org/10.1016/j.jhazmat.2018.10.072] [PMID: 30388639]
[79]
Xing, M.; Zhang, Y.; Zou, H.; Quan, C.; Chang, B.; Tang, S.; Zhang, M. Exposure characteristics of ferric oxide nanoparticles released during activities for manufacturing ferric oxide nanomaterials. Inhalation Toxicology, 2015, 27(3), 138-148.
[http://dx.doi.org/10.3109/08958378.2014.1001535]
[80]
Bäumler, W. Absorption, distribution, metabolism and excretion of tattoo colorants and ingredients in mouse and man: the known and the unknown. Curr. Probl. Dermatol., 2015, 48, 176-184.
[http://dx.doi.org/10.1159/000369222] [PMID: 25833641]
[81]
Boskabady, M.; Marefati, N.; Farkhondeh, T.; Shakeri, F.; Farshbaf, A.; Boskabady, M.H. The effect of environmental lead exposure on human health and the contribution of inflammatory mechanisms, a review. Environ. Int., 2018, 120, 404-420.
[http://dx.doi.org/10.1016/j.envint.2018.08.013] [PMID: 30125858]
[82]
Tariq, M. Toxicity of Mercury in Human: A review toxicity of mercury in human: A review. J. Clin. Toxicol., 2019, 9, 431.
[83]
Nordberg, G.F.; Bernard, A.; Diamond, G.L.; Duffus, J.H.; Illing, P.; Nordberg, M.; Skerfving, S. Risk assessment of effects of cadmium on human health (IUPAC Technical Report). Pure Appl. Chem., 2018, 90(4), 755-808.
[http://dx.doi.org/10.1515/pac-2016-0910]
[84]
Schmitz, I.; Prymak, O.; Epple, M.; Ernert, C.; Tannapfel, A. Squamous cell carcinoma in association with a red tattoo. J. Dtsch. Dermatol. Ges., 2016, 14(6), 604-609.
[http://dx.doi.org/10.1111/ddg.12730] [PMID: 27240068]
[85]
Liszewski, W.; Warshaw, E.M. Pigments in American tattoo inks and their propensity to elicit allergic contact dermatitis. J. Am. Acad. Dermatol., 2019, 81(2), 379-385.
[http://dx.doi.org/10.1016/j.jaad.2019.01.078] [PMID: 30731175]
[86]
Tubek, K.; Berus, T.; Leszek, R. The girl with the eyeball tattoo-what the ophthalmologist may expect? Case report and a review of literature. Eur. J. Ophthalmol., 2019, 29(5), NP1-NP4.
[http://dx.doi.org/10.1177/1120672118803855] [PMID: 30284451]
[87]
Rodríguez- Avila. J.; Valles- Valles, D.; Hernández- Ayuso, I. Conjunctival tattoo with inadvertent ocular globe penetration and vitreous involvement: Clinico-pathological correlation and scanning electron microscopy X-ray microanalysis; Eur. J. Ophthal, 2019.
[http://dx.doi.org/1120672119850076]
[88]
Riffo, G.; Ramírez-Lama, C.; Bennun, L. Elemental quantification in intradermal tattoo-inks by means of total reflection X-Ray fluorescence. J. Cosmet. Dermatol. Sci. Appli., 2020, 10, 33-53.
[89]
Sabbioni, G.; Hauri, U. Carcinogenic tattoos? Epidemiol. Biostat. Public Health, 2016, 13(4), e12018-1-e12018-3.
[90]
Dréno, B. Tattoo and sarcoidosis reaction. Bull. Acad Natl. Med., 2020, 204(6), 611-615.
[PMID: 32322103]
[91]
Shubhangi, K.; Alka, D.; Neha, U.; Kumar, M.R.; Shalini, G. Cancer risk in tattoos: A review. IOSR J. Dent. Med. Sci., 2013, 5(1), 62-64.
[http://dx.doi.org/10.9790/0853-0516264]
[92]
Bagot, M. Complications of tattoos: Clinical and pathological classification, pathophysiology, particle kinetics. Bull. Acad Natl. Med., 2020, 204(6), 607-610.
[http://dx.doi.org/10.1016/j.banm.2020.04.013] [PMID: 32322105]
[93]
Bose, R.; Sibley, C.; Fahim, S. Granulomatous and systemic inflammatory reactions from tattoo ink: Case report and concise review. SAGE Open Med. Case Rep., 2020, 8, X20936036.
[http://dx.doi.org/10.1177/2050313X20936036] [PMID: 32782801]
[94]
Shetty, S.K.; Hegde, U.; Jagadish, L.; Shetty, C. Pseudolymphoma versus lymphoma: An important diagnostic decision. J. Oral Maxillofac. Pathol., 2016, 20(2), 328-330.
[http://dx.doi.org/10.4103/0973-029X.185909] [PMID: 27601833]
[95]
Paprottka, F.J.; Krezdorn, N.; Narwan, M.; Turk, M.; Sorg, H.; Noah, E.M.; Hebebrand, D. Trendy tattoos-maybe a serious health risk? Aesthetic Plast. Surg., 2018, 42(1), 310-321.
[http://dx.doi.org/10.1007/s00266-017-1002-0] [PMID: 29124377]
[96]
Cohen, P.R.; Erickson, C.P.; Uebelhoer, N.S.; Calame, A. Tattoo-associated basal cell carcinoma: coincident or coincidence. Biomed. Hub, 2020, 5(2), 2055-2062.
[http://dx.doi.org/10.1159/000508208] [PMID: 32884932]
[97]
Paprottka, F.J.; Bontikous, S.; Lohmeyer, J.A.; Hebebrand, D. Squamous-cell carcinoma arises in red parts of multicolored tattoo within months. Plast. Reconstr. Surg. Glob. Open, 2014, 2(3), e114.
[http://dx.doi.org/10.1097/GOX.0000000000000055] [PMID: 25289308]
[98]
Kluger, N.; Koljonen, V. Tattoos, inks, and cancer. Lancet Oncol., 2012, 13(4), e161-e168.
[http://dx.doi.org/10.1016/S1470-2045(11)70340-0] [PMID: 22469126]
[99]
Kluger, N.; Douvin, D.; Dupuis-Fourdan, F.; Doumecq-Lacoste, J.M.; Descamps, V. [Keratoacanthomas on recent tattoos: Two cases] Ann. Dermatol. Venereol., 2017, 144(12), 776-783.
[http://dx.doi.org/10.1016/j.annder.2017.10.006] [PMID: 29126557]
[100]
Kruger, N. Improving patient outcomes: decorative tattoos, breast cancer and lymphoedema. Wounds UK, 2018, 14(2), 12-16.
[101]
Kluger, N.; Koskenmies, S.; Jeskanen, L.; Övermark, M.; Saksela, O. Melanoma on tattoos: two Finnish cases. Acta Derm. Venereol., 2014, 94(3), 325-326.
[http://dx.doi.org/10.2340/00015555-1705] [PMID: 24096729]
[102]
Joyce, C.W.; Duff, G.; McKenna, D.; Regan, P.J. Malignant melanoma arising in red tattoo ink. Arch. Plast. Surg., 2015, 42(4), 475-477.
[http://dx.doi.org/10.5999/aps.2015.42.4.475] [PMID: 26217569]
[103]
Junqueira, A.L.; Wanat, K.A.; Farah, R.S. Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management. Clin. Exp. Dermatol., 2017, 42(6), 601-606.
[http://dx.doi.org/10.1111/ced.13183] [PMID: 28661073]
[104]
Ricci, F.; Paradisi, A.; Maier, S-A.; Kovacs, M.; Podda, M.; Peris, K.; Abeni, D. Melanoma and tattoos: a case report and review of the literature. Eur. J. Dermatol., 2018, 28(1), 50-55.
[PMID: 29171408]
[105]
Hutton Carlsen, K.; Sepehri, M.; Serup, J. Tattooist-associated tattoo complications: Overworked Tattoo, Pigment Over load and infections producing early and late adverse events. Dermatology, 2020, 9, 1-8.
[http://dx.doi.org/10.1159/000501962]
[106]
Grodner, C.; Beauchet, A.; Fougerousse, A.C. Tattoo complications in treated and non-treated psoriatic patients. J. Eur. Acad. Dermatol. Venereol., 2020, 34(4), 888-896.
[http://dx.doi.org/10.1111/jdv.15975]
[107]
Lehner, K.; Santarelli, F.; Vasold, R.; Penning, R.; Sidoroff, A.; König, B.; Landthaler, M.; Bäumler, W. Black tattoos entail substantial uptake of genotoxicpolycyclic aromatic hydrocarbons (PAH) in human skin and regional lymph nodes. PLoS One, 2014, 9(3), e92787.
[http://dx.doi.org/10.1371/journal.pone.0092787] [PMID: 24670978]
[108]
Sepehri, M.; Sejersen, T.; Qvortrup, K.; Lerche, C.M.; Serup, J. Tattoo pigments are observed in the Kupffer cells of the liver indicating blood-borne distribution of tattoo ink. Dermatology, 2017, 233(1), 86-93.
[http://dx.doi.org/10.1159/000468149] [PMID: 28486229]
[109]
Abudu, B.; Erickson, C.P.; Calame, A.; Cohen, P.R. Basal cell carcinoma originating in a tattoo: case report and review of an uncommon complication in tattoo recipients. Dermatol. Pract. Concept., 2019, 9(4), 265-270.
[http://dx.doi.org/10.5826/dpc.0904a03] [PMID: 31723458]
[110]
Falconi, M.; Teti, G.; Zago, M.; Galanzi, A.; Breschi, L.; Pelotti, S.; Ruggeri, A.; Mazzotti, G. Influence of a commercial tattoo ink on protein production in human fibroblasts. Arch. Dermatol. Res., 2009, 301(7), 539-547.
[http://dx.doi.org/10.1007/s00403-009-0953-7] [PMID: 19373482]
[111]
Regensburger, J.; Lehner, K.; Maisch, T.; Vasold, R.; Santarelli, F.; Engel, E.; Gollmer, A.; König, B.; Landthaler, M.; Bäumler, W. Tattoo inks contain polycyclic aromatic hydrocarbons that additionally generate deleterious singlet oxygen. Exp. Dermatol., 2010, 19(8), e275-e281.
[http://dx.doi.org/10.1111/j.1600-0625.2010.01068.x] [PMID: 20545755]
[112]
Hering, H.; Zoschke, C.; Kühn, M.; Gadicherla, A.; Weindl, G.; Luch, A.; Schreiver, I. TatS: a novel in vitro tattooed human skin model for improved pigment toxicology research. Archives of Toxicology, 2020, 94, 2423-2434.
[http://dx.doi.org/10.1007/s00204-020-02825-z]
[113]
Homolak, J. The effect of a color tattoo on the local skin redox regulatory network: an N-of-1 study, 2020.https://www.researchgate.net/publication/342163122
[114]
Beliveau, J.; Perreault-Briere, M.; Jeker, D.; Deshayes, T.A.; Durán-Suárez, A.; Baker, L.B.; Goulet, E.D.B. Permanent tattooing has no impact on local sweat rate, sweat sodium concentration and skin temperature or prediction of whole-body sweat sodium concentration during moderate-intensity cycling in a warm environment. Eur. J. Appl. Physiol., 2020, 120(5), 1111-1122.
[http://dx.doi.org/10.1007/s00421-020-04350-4] [PMID: 32232657]
[115]
Bolt, H.; Hengstler, J. Tattoo toxicology, an upcoming complex scientific issue. Archives of Toxicology, 2020.
[http://dx.doi.org/10.1007/s00204-020-02822-2]
[116]
Swigost, A.; Farah, R.S.; Canova, E.; Goldfarb, N. Multiple squamous neoplasms arising in a red tattoo after laser tattoo removal. Dermatol. Surg., 2019, 00, 1-3.
[http://dx.doi.org/10.1097/DSS.0000000000002031]
[117]
Al-Sa’ady, A.J.R. Comparison between PPO from plant sources and different chemicals in tattoo dyes decolorization. Iraqi Journal of Agricultural Sciences, 2020, 51(2), 550-555.
[http://dx.doi.org/10.36103/ijas.v51i2.981]
[118]
Karymov, O.; Vorobyov, A.; Kalashnikova, S.; Polyakova, L.; Vyskub, M. Betamethasone administration as a treatment of choice in local post- tattoo complications. Pharmacy and Pharmacology, 2020, 8(1), 48-56.
[http://dx.doi.org/10.19163/2307-9266-2020-8-1-48-56]
[119]
Rahimi, I.A.; Eberhard, I.; Kasten, E. Tattos: what do people really know about the medical risks of body ink? J. Clin. Aesthet. Dermatol., 2018, 11(3), 30-35.
[PMID: 29606998]
[120]
Hering, H. YuSung, A.; Röder, N. Laser irradiation of organic tattoo pigments releases carcinogens with 3,3′- dichlorobenzidine inducing DNA strand breaks in human skin cells. J Invest Dermatol., 2018, 138(12), 2687-2690.
[http://dx.doi.org/10.1016/j.jid.2018.05.031]
[121]
Neale, P.A.; Stalter, D.; Tang, J.Y.M.; Escher, B.I. Bioanalytical evidence that chemicals in tattoo ink can induce adaptive stress responses. J. Hazard. Mater., 2015, 296, 192-200.
[http://dx.doi.org/10.1016/j.jhazmat.2015.04.051] [PMID: 25929673]
[122]
Foerster, M.; Schreiver, I.; Luch, A.; Schüz, J. Tattoo inks and cancer. Cancer Epidemiol., 2020, 65, 101655.
[http://dx.doi.org/10.1016/j.canep.2019.101655] [PMID: 31836426]
[123]
Kluger, N. An update on cutaneous complications of permanent tattooing. Journal Expert Review of Clinical Immunology, 2019, 15(11), 1135-1143.
[http://dx.doi.org/10.1080/1744666X.2020.1676732]
[124]
Petrochko, J.M.; Krakowski, A.C.; Donnelly, C.; Wilson, J.B.; Irick, J.B.; Stawicki, S.P. Tattooassociated complications and related topics: A comprehensive review. Int. J. Acad. Med., 2019, 5(1), 19-50.
[http://dx.doi.org/10.4103/IJAM.IJAM_13_19]
[125]
Giulbudagian, M.; Schreiver, I.; Singh, A.V.; Laux, P.; Luch, A. Safety of tattoos and permanent make-up: a regulatory view. Arch. Toxicol., 2020, 94, 357-369.
[http://dx.doi.org/10.1007/s00204-020-02655-z]