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Letters in Organic Chemistry

Author(s): Wenhua Ou, Ruolin Wang, Ruonan Liu and Hong Huang*

DOI: 10.2174/1570178618666210217121023

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An Improved and Suitable Method for Large Scale Production of α-Monochlorocyclodecanone

Page: [418 - 421] Pages: 4

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Abstract

α-Monochlorocyclododecanone was synthesized from cyclododecane and 1,3-Dichloro-5,5- dimethylhydantoin (DCDMH) catalyzed with silica gel in MeOH. The product was obtained by crystallization with a nearly 85% yield. The presented method used cheap raw materials, mild reaction conditions, a simple separation method, and an environment-friendly process. Additionally, the current synthesis provided an ideal approach for large-scale production.

Keywords: α-Monochlorocyclododecanone, synthesis, cyclododecane, DCDMH, environment-friendly procedure, large-scale production.

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