Abstract
Introduction: COVID-19 pandemic represents a major health issue caused by SARS
CoV2, a human coronavirus. Since the outbreak of this pandemic, the literature on SARS CoV-2
has grown differentially, with increased awareness of extra-respiratory symptoms, including neurological
symptoms.
Methods: Review based on studies published from December 2019 to June 2020.
Results and Discussion: This review discusses the neurological aspect of SARS CoV2, including
the suggested mechanism involved. Neurological disorders are cited in addition to emerging experimental
models with viral involvement.
Conclusion: There is a need for further investigation to clarify how it can lead to the onset of acute
and chronic neurological disorders, mentioning the importance of experimental studies in neuropsychopharmacology.
Keywords:
COVID-19, SARS CoV2, nervous system, neuropsychopharmacology, neurological disorders, central nervous system.
[6]
Desforges M, Le Coupanec A, Dubeau P, et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 2019; 12(1): 14. http://dx.doi.org/10.3390/v12010014 PMID: 31861926
[8]
Yeh EA, Collins A, Cohen ME, Duffner PK, Faden H. Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis. Pediatrics 2004; 113(1 Pt 1): e73-6. PMID: 14702500
[9]
Desforges M, Favreau D J, Brison É, et al. Human Coronaviruses: Respiratory pathogens revisited as infectious neuroinvasive, neurotropic, and neurovirulent agents. 2013.
[12]
Li YC, Bai WZ, Hashikawa T. Response to Commentary on “The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients”. J Med Virol 2020; 92(7): 707-9. http://dx.doi.org/10.1002/jmv.25824 PMID: 32246783
[17]
Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. Aspiration Pneumonia Caused by Neuromyelitis Optica in a Patient with Suspected COVID-19. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY 2020; 4(2): 138-41.
[18]
Zhao Y, Liu J, Wu S, et al. Aspiration Pneumonia Caused by Neuromyelitis Optica in a Patient with Suspected COVID-19. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY 2020; 4(2): 138-41.
[19]
Zhang Q L, Ding Y Q, Hou J L, et al. Detection of severe acute respiratory syndrome (SARS)-associated coronavirus RNA in autopsy tissues with in situ hybridization. Di 1 jun yi da xue xue bao= Academic journal of the first medical college of PLA 2003; 23(11): 1125-7.
[20]
Xu X W, Wu X X, Jiang X G, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. bmj 2020; 368.
[25]
Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G. Is COVID-19 an endothelial disease? Clin Basic Evid 2020.