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Current Drug Targets

Author(s): Lisa Toto*, Luca Di Antonio, Olivia Costantino and Rodolfo Mastropasqua

DOI: 10.2174/1389450122999210128180725

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Anti-VEGF Therapy in Myopic CNV

Page: [1054 - 1063] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

In this narrative-review, we report the most recent data from the literature of anti-vascular endothelial growth factor treatment for myopic choroidal neovascularization (mCNV). Myopic CNV is the most frequent sight-threatening complication of pathologic myopia. The natural course of mCNV can result in expanding macular atrophy and /or fibrosis, leading to irreversible visual loss after 5 years. Retinal multimodal imaging is mandatory for early diagnosis and monitoring of the disease during treatment. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is recommended as the first-line treatment option for mCNV. Prompt treatment of active mCNV with intravitreal anti-VEGF therapy has been demonstrated to be effective in terms of visual outcome improvements reducing the occurrence of late-stage complications.

Keywords: Myopic choroidal neovascularization, anti-vascular endothelial growth factor therapy, pathologic myopia, fundus fluorescein angiography, bevacizumab, ranibizumab, aflibercept.

Graphical Abstract

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