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Letters in Organic Chemistry

Author(s): Amita J. Jivani, Khushal M. Kapadiya and Ranjan C. Khunt*

DOI: 10.2174/1570178618666210125161922

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Miscellaneous Passerini Reaction for α-Acyloxy Carboxamide: Synthesis and Process Optimization Study

Page: [326 - 332] Pages: 7

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Abstract

“Phase Transfer Catalyst” as additive was exposed to the Passerini three-component reactions and the influence of its accelerating effect on the reaction rate was studied concerning direct involvement of reactant molecules. For the rapid formation of diverse “α-acyloxycarboxamides” using passerini reaction, multicomponent reactions were employed using miscellaneous 2-(prop-2-ynyloxy) benzaldehyde with various aromatic acids and slightly non-polar fragment, i.e. 2-isocyano-2,3,3- trimethylbutane, and the representative molecule was characterized with DEPT-135 NMR technique.

Keywords: Multicomponent reactions (MCR’s), Passerini Reaction, α-Acyloxy carboxamides linkage, DEPT-135 NMR, Phase transfer catalyst.

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