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Current Radiopharmaceuticals

Author(s): Sara Vosoughi, Nafise Salek *, Simindokht Shirvani Arani, Ali Bahrami Samani and Mohammad Ghannadi Maragheh

DOI: 10.2174/1874471014666210122150134

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Investigation of Radiolabeling Efficacy by Enhancement of the Chemical form of no Carrier Added 177Lu Isolated by Electro Amalgamation Process

Page: [56 - 62] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Background: Due to the suitable nuclear decay characteristics, 177Lu is an attractive radionuclide for various therapeutic applications. The non-carrier added form of177Lu has drawn much attention because of its high specific activity needed in radiolabeling studies. There have been several separation methods for NCA177Lu production.

Objectives: Among the various separation methods, the electro-amalgamation separation method has got a large potential for large scale production. Li presence is a significant problem in this separation method, which seriously affects the radiolabeling efficiency.

Methods: In this study, Li was separated from the final product of electro-amalgamation separation by adding an ion-exchange chromatography column to the separation process.

Results: NCA 177Lu was obtained by 84.09% ELM separation yield, 99.9% radionuclide purity and, 65 Ci/g specific activity. Then, 177Lu (177LuCl3 chemical form) was separated from Li using the ion exchange chromatography method by a separation yield of 94%. The obtained results of the radiolabeling efficacy studies showed that the radiochemical purity and radio-complex stability were significantly increased by separating NCA 177Lu from Li.

Conclusion: This new separation setup consisting of two steps allows using 177Lu of such a favorable quality for labeling studies.

Keywords: 177Lu, electro-amalgamation separation, 5, 10, 15, 20-tetrakis(phenyl)porphyrin (TPP), radiolabeling efficacy.

Graphical Abstract

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